Instalab ResearchVO2 max is the maximum rate at which the body can take in, transport, and use oxygen during exercise. It is measured in milliliters of oxygen per kilogram of body weight per minute (mL/kg/min). The test is usually performed on a treadmill or stationary bike while exercise intensity increases until exhaustion.
A higher VO2 max means that the cardiovascular and muscular systems can sustain higher workloads with less fatigue. Elite endurance athletes may have VO2 max scores above 70 mL/kg/min, while sedentary individuals often measure below 30. Although genetics set a baseline, VO2 max is highly trainable through targeted exercise. This trainability is one reason it is considered a vital health marker rather than a fixed trait.
VO2 max is not just about sports performance. It predicts cardiovascular health, independence in older age, and mortality risk more strongly than many conventional health measures. Large cohort studies show that higher cardiorespiratory fitness, often quantified by VO2 max, is associated with a lower risk of all-cause mortality. Even modest increases translate into meaningful reductions in risk.
In clinical populations, VO2 max is particularly important. In patients with heart failure, aerobic training improves VO2 max and quality of life. In those with diabetes, higher VO2 max is linked to better glucose control. In people recovering from cardiac events, exercise-based rehabilitation programs use VO2 max as a key measure of progress.
Maintaining or improving VO2 max throughout life is therefore one of the most effective ways to extend both lifespan and healthspan.
Aerobic Training — The most established method for improving VO2 max is aerobic training. Activities like running, cycling, rowing, and swimming strengthen the heart, increase stroke volume, and expand the oxygen delivery system. Systematic reviews of randomized controlled trials show that aerobic training significantly improves VO2 max in both healthy and unhealthy populations.
Interval Training — Interval training pushes VO2 max adaptations further by alternating high-intensity effort with recovery. Research suggests this method provides a stronger stimulus than continuous training alone. Interval training also improves blood sugar control, providing dual benefits for both fitness and metabolic health.
Combined Aerobic and Resistance Training — While aerobic training is superior for improving VO2 max, resistance training provides additional benefits such as increased muscle mass and bone density. Combining the two may yield the most comprehensive health outcomes. Randomized controlled trials in overweight patients have shown that combined aerobic and resistance training consistently improves VO2 max while also reducing body mass index.
High-Intensity, Low-Volume Approaches — Some individuals cite time as the greatest barrier to regular training. High-intensity, low-volume interval training has emerged as a time-efficient alternative. Randomized controlled trials reveal that just a few short sessions per week of high-intensity training can significantly improve VO2 max, sometimes in as little as four weeks. Even with far less exercise time, improvements can match or exceed those seen with longer, moderate sessions.
The decline of VO2 max with age is one of the strongest contributors to reduced independence and higher mortality risk. Encouragingly, studies show that targeted exercise attenuates this decline. In older adults, randomized controlled trials consistently demonstrate that aerobic training, interval training, or combined programs improve VO2 max within weeks to months. Long-term follow-up shows that these improvements can be sustained for a year or more when exercise becomes a habit.
Even in patients with chronic diseases, VO2 max improvements are possible. For example, in heart failure patients, compliant participation in aerobic and combined training programs significantly improved peak oxygen uptake and muscular endurance. The message is clear: VO2 max can be improved at virtually any age or health status, provided training is tailored to individual capacity and maintained consistently.
Improving VO2 max does not require extreme measures, but it does require consistency and progression. Based on the strongest evidence, the following approach is practical for most people:
