Instalab
2025.03.06  |  Heart Health
A Smarter Way to Choose Cholesterol Medication
When it comes to lowering cholesterol, most doctors start with a statin. These medications have been used for decades, are backed by research, and work well for many people. But not everyone responds the same way. Some people see great results, while others experience little improvement. So how do you know which medication will work best for you?
Alex Cheung

The Usual Process: Guess and Adjust

Doctors typically prescribe a standard dose of a statin, like atorvastatin (Lipitor), and check cholesterol levels after a few months. If it's working, great. If not, they may increase the dose or try another drug. This cycle continues until they find the right fit. Meanwhile, you might deal with side effects, uncertainty, and wasted time.

Sterol testing offers a shortcut. It identifies whether your cholesterol problem is due to absorbing too much from food or making too much in your liver. With this information, your doctor can choose the right medication from the beginning.

What Is Sterol Testing?

Sterols are natural substances in your body that help process cholesterol. A sterol test measures them to see if your cholesterol issue comes from absorption or production.

Plant Sterols (Sitosterol & Campesterol)

  • Come from foods like nuts, seeds, and whole grains.
  • If levels are high, it means your body is absorbing too much cholesterol from food.

Cholesterol Precursors (Lathosterol & Desmosterol)

  • Made by your liver when it produces cholesterol.
  • If these are high, your liver is making too much cholesterol on its own.

How This Guides Medication Choice

Knowing whether your cholesterol comes from absorption or production helps pick the best treatment:

If You Absorb Too Much (High Sitosterol & Campesterol)

  • Problem: Your intestines let in too much cholesterol from food.
  • Best Medication: Ezetimibe (Zetia), which blocks cholesterol absorption.

If Your Liver Makes Too Much (High Lathosterol & Desmosterol)

  • Problem: Your body is producing too much cholesterol internally.
  • Best Medication: Statins like rosuvastatin, which slow down cholesterol production.

If Both Absorption & Production Are High

  • Problem: Your cholesterol levels are high for both reasons.
  • Best Treatment: A combination of a statin and ezetimibe to target both sources.

Why This Matters

The typical approach to cholesterol treatment involves guessing, adjusting, and waiting months to see results. Sterol testing eliminates much of that uncertainty. It helps doctors personalize treatment so you start on the right medication immediately, reducing trial and error, side effects, and frustration.

By using sterol testing, cholesterol treatment becomes more precise—helping you get the best results as quickly and effectively as possible.

Get Professional Help with Instalab

If you're serious about lowering your cholesterol and optimizing your heart health, our Heart Health Program at Instalab provides expert guidance to do just that. With the help of a lipid specialist, we create a personalized treatment plan tailored to your unique cholesterol profile. Sterol testing is just one of the advanced tools we use to pinpoint the most effective medication for you.

Beyond just identifying the right medication, we handle prescription management, monitor your progress, and adjust your treatment as needed until you reach your ideal cholesterol levels. Instead of spending unnecessary time on trial and error, our program ensures you're on the most effective treatment from day one.