2-minute questionnaire
Tell us about your current and recent blood pressure readings, kidney function, diabetes status, and any prior blood pressure medications. We ask the same questions a cardiologist or nephrologist would.
InstalabLosartan · 25–100mg · generic Cozaar®
Lower blood pressure. Protect your kidneys.
Losartan (generic Cozaar®) is an ARB that drops blood pressure 8–15 mmHg and slows kidney disease in type 2 diabetics with nephropathy. Prescription, titration, and physician follow-up included.
8–15mmHg systolic BP reduction
28%Less progression to ESRD (RENAAL)
25%Stroke reduction in HTN + LVH (LIFE)
Losartan · once daily · titrated to a blood-pressure target
Licensed US physician review
12,000+ patients treated
Available in all 50 states
Ongoing follow-up
How it works
From questionnaire to first dose.
No clinic visits. A licensed physician reviews your case, picks the right starting dose, and titrates it to your target. We handle labs, refills, and follow-up.
Physician review
A licensed physician confirms losartan is appropriate, screens for contraindications (pregnancy, severe volume depletion, prior ARB-related angioedema), and writes your starting prescription. Usually within 1 business day.
Prescription sent to your pharmacy
Your physician routes the prescription to the pharmacy of your choice. Pick it up, or have your pharmacy deliver if they offer it. Generic losartan is on essentially every formulary, so it's usually ready the same or next day.
BP recheck and titration
Recheck blood pressure at 2 to 4 weeks. Recheck a basic metabolic panel (potassium, creatinine) at the same time. If you are not at your BP target, your physician titrates up toward 100mg or adds a second agent.
Pricing
What you'll actually pay.
Two line items: Instalab Membership and the losartan medication itself, dispensed by your pharmacy. No prescription fees, no per-titration fees.
Instalab Membership
Physician oversight, titration management, lab follow-up, and ongoing care
$—/mo
Losartan
Generic, dispensed by your pharmacy
Cash price$5–14/monthTypical pharmacy cash price
With insurance$0–10/monthTypical copay, if covered
Why pay a membership fee? Losartan is cheap, but getting blood pressure to target and protecting your kidneys takes ongoing titration, BMP monitoring (potassium and creatinine), and home BP review. Membership covers the visits, dose changes, and pharmacy coordination. You pick up the prescription at your own pharmacy and pay them directly for the medication; labs are billed separately.
Will my insurance cover losartan?
Losartan is on essentially every commercial and Medicare formulary as a tier-1 generic, so insurance copays are typically $0 to $10 per month. Cash price at most pharmacies is similar — usually $4 to $15 per month with a discount card. We send the prescription to whichever pharmacy you'd like; you handle pickup and payment with them directly.
Why membership
Losartan works. Getting to target takes ongoing care.
It needs a physician who titrates the dose to your home BP readings, monitors potassium and kidney function, and adjusts the plan as your numbers evolve. Here's how our team handles that for you.
- Week 1Day 1–5
Physician evaluation and starting prescription
A licensed physician reviews your blood pressure history, kidney function, and medications, then writes your starting prescription. Most adults start at 50mg daily; older adults, patients with hepatic impairment, or volume-depleted patients start at 25mg.
- Week 1–4
Pickup and first doses
Pick up your losartan from the pharmacy you chose. Take it once daily, with or without food, at the same time each day. Some people feel lightheaded with the first dose, especially if dehydrated. Watch your home BP twice daily for the first week.
- Week 2–4
First recheck
Recheck blood pressure (home readings or in office) and a basic metabolic panel (potassium and creatinine). Most of the BP drop has happened by now. Your physician decides whether to hold the dose, titrate up to 100mg, or add a second agent. Labs are billed separately.
- OngoingMonth 2+
Titration and renewals
Step up to 100mg if BP is not at target; add a thiazide or calcium channel blocker if losartan alone is not enough. Once you are at target, we keep your prescription active and recheck BP and labs periodically. Antihypertensive therapy is generally lifelong; we make staying on it easy.
Without membership
Schedule a PCP visit. Wait weeks. Get a prescription. Schedule another visit for the recheck. Hope they remember to titrate and order the BMP. Track BP between visits yourself.
With Instalab
2-minute questionnaire. Physician review within 1 business day. Lab orders, titration, and refills handled. Care team a message away if you have a side effect or your BP is not moving.
About the medication
A simple daily routine, backed by data.
One small pill, once a day, with or without food. Most patients see blood pressure drop within hours, with full effect by 3 to 6 weeks.
- One pill, once a dayTake it at the same time each day. Pick a time that fits your routine and stay consistent.
- Best taken with home BP monitoringA home BP cuff and twice-daily readings during titration help you and your physician dial in the right dose. Targets and frequency are personalized to your risk profile.
- BMP recheck during titrationA basic metabolic panel (potassium and creatinine) at 2 to 4 weeks confirms the kidneys are tolerating the medication and potassium is in range. Labs are billed separately.
- Ongoing supportOur care team is a message away. Reach out if your BP is not moving, you feel lightheaded, or you have any side effect.
Why losartan
The first ARB with outcome trials.
Losartan blocks the AT1 receptor where angiotensin II would normally bind to constrict blood vessels and signal the adrenal glands to retain salt and water. With that signal blocked, vessels relax, sodium is excreted, and blood pressure falls. Unlike ACE inhibitors, losartan doesn't raise bradykinin levels — so the dry cough that troubles many people on ACE inhibitors is uncommon with losartan.
- Lowers blood pressure 8 to 15 mmHgIn monotherapy, losartan typically drops systolic blood pressure 8 to 15 mmHg and diastolic 4 to 8 mmHg. Combined with a thiazide diuretic, the drop is larger.
- Slows kidney disease in diabetesIn the RENAAL trial, losartan reduced the risk of doubling serum creatinine, end-stage renal disease, or death by 16% in patients with type 2 diabetes and nephropathy compared with placebo plus standard care.
- Cut stroke risk in hypertension with LVHIn the LIFE trial, losartan reduced the composite of cardiovascular death, myocardial infarction, or stroke by 13% versus atenolol in patients with hypertension and left ventricular hypertrophy, with a 25% reduction in stroke specifically.
The LIFE and RENAAL trials
Two pivotal trials published in The Lancet and NEJM in the early 2000s established losartan as more than just a blood-pressure pill. LIFE (9,193 patients, hypertension with LVH) showed losartan cut major cardiovascular events 13% versus atenolol, driven by a 25% reduction in stroke. RENAAL (1,513 patients, type 2 diabetes with nephropathy) showed losartan reduced progression to end-stage kidney disease by 28% versus standard care. Together they established the ARB class as protective beyond blood pressure alone.
8,851
Patients combined (LIFE + RENAAL)
25%
Stroke risk reduction vs atenolol (LIFE)
28%
ESRD reduction in diabetic nephropathy (RENAAL)
Real results
What losartan looks like in practice.
Three patients, four to twelve weeks in.
152134Home SBP mmHg6 weeks on 50mg
“I avoided BP meds for years. Six weeks in, my home readings dropped from 150s to mid-130s with zero side effects. Wish I had started earlier.”
168138Home SBP mmHg8 weeks on 100mg
“My PCP had me on lisinopril and the cough was unbearable. Switched to losartan and the cough was gone in a week. BP came down even more once we got to 100mg.”
158132Home SBP mmHg12 weeks on 50mg
“I have type 2 diabetes and my urine started showing protein. My physician picked losartan specifically for the kidney protection. Three months in, BP is at target and my microalbumin has come down.”
Losartan is a prescription medicine. Important safety information applies. Most patients tolerate it well. It cannot be used during pregnancy. Your physician will check potassium and kidney function early in treatment.
Ready when you are
Get blood pressure to target.
Answer the questionnaire. A physician reviews your case and, if losartan is appropriate, prescribes it. We handle titration, lab follow-up, and refills so you actually hit your BP target.
No commitment to treatment.