High Quality Resveratrol Supplements

Resveratrol is a polyphenol that activates sirtuins (longevity-related enzymes), supports endothelial function, and has antioxidant effects. It's been studied for cardiovascular health, blood sugar, and cellular aging pathways.

100–500 mg/day. Trans-resveratrol (the bioactive form) at 250–500 mg shows effects on metabolic markers in studies. Higher doses (1–2 g) have been used in research but may cause GI upset.

With a meal containing fat for better absorption. Pairing with quercetin or piperine may improve bioavailability. Some longevity protocols pair resveratrol with NAD precursors (NMN/NR), though benefit of stacking isn't proven.

To get a 250 mg dose from red wine you'd need 100+ glasses. The amounts in wine are too low to replicate study doses, and the alcohol negates benefits. Supplements provide therapeutic doses without the alcohol load.

Trans-resveratrol is the active form used in clinical research. Cis-resveratrol forms when trans is exposed to light or heat and has weaker biological activity. Look for products specifying high trans-resveratrol content (98%+).

Effects on metabolic markers (insulin sensitivity, blood pressure) typically appear within 4–12 weeks. Cellular and longevity benefits accumulate over months to years and aren't directly felt — they're inferred from biomarkers.

Red grape skins, red wine (small amounts), peanuts, dark chocolate, and some berries (lingonberries, blueberries). Japanese knotweed (Polygonum cuspidatum) is the main commercial source for supplements.

In animal studies, yes — but dose-equivalents and species differences matter. In humans, evidence is strongest for metabolic health and cardiovascular markers. Direct lifespan extension hasn't been proven.