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InstalabLeqvio · 284mg · inclisiran injection
Two shots a year. LDL and ApoB cut in half.
Leqvio (inclisiran) is a siRNA therapy that silences PCSK9 in the liver. A mobile nurse comes to you for two starter doses, then one injection every six months. Instalab handles presecription, lab tracking, and ongoing care.
~50%LDL and ApoB reduction
2x/yrAfter loading phase
No waiting roomsMobile nurse comes to you
Leqvio 284mg · mobile nurse injection · every 6 months
Licensed US physician review
Mobile nurse administration
Available in all 50 states
Ongoing physician follow-up
How it works
From questionnaire to first injection.
No clinic visits. A licensed physician reviews your case and recent labs, confirms eligibility, and a mobile nurse administers the injection at your home or office.
Physician review
A board-certified lipidologist evaluates your eligibility, usually within one business day, and reaches out if anything else is needed.
Mobile nurse visit
A licensed nurse comes to your preferred location to administer the first injection. The actual shot takes seconds.
Lab recheck and ongoing care
Recheck LDL and ApoB around 8 weeks. Second dose at month 3, then one injection every 6 months. We track results and renewals so you stay on plan.
Pricing
What you'll actually pay.
Two line items: Instalab Membership and the Leqvio medication itself, dispensed directly by Novartis. No hidden fees.
Instalab Membership
Physician oversight, mobile nurse coordination, and ongoing follow-up
$—/mo
Leqvio 284mg
Inclisiran injection, dispensed by Novartis
Cash price$4,000/injectionCash price
With insurance$0–100/injectionTypical copay, if covered
Membership covers physician visits, mobile nurse scheduling, prior authorization, renewals and concierge support. Lab costs and the medication itself are billed separately.
Will my insurance cover Leqvio?
Some commercial plans cover Leqvio for patients with established cardiovascular disease, familial hypercholesterolemia, and documented statin intolerance. We check your plan and file the prior authorization either way.
Why membership
Leqvio works. Twice-yearly dosing takes ongoing care.
It needs a physician who knows the drug, a mobile nurse for each dose, and regular labs to confirm it's working. Here's how our team handles that for you.
- Week 1Day 1–7
Physician review and eligibility
A board-certified lipidologist reviews your labs and history, confirms Leqvio is right for you, and writes the prescription. We verify your insurance and enroll you in Novartis patient assistance in parallel.
- Week 2–4
First mobile nurse visit
A licensed nurse comes to your home or office to administer the first injection. The injection itself takes seconds. We check in the next day.
- Week 8
Confirm it's working
Recheck LDL and ApoB. Your physician reviews the results with you. Most patients see LDL and ApoB drop sharply, with full effect after the second dose. Labs are billed separately.
- Month 3
Second dose, then twice yearly
A nurse comes back for the second loading dose at month 3. After that, one injection every six months keeps LDL consistently low. We schedule each visit, track your labs, and keep your prescription active.
Without membership
Track down a lipidologist who actually knows the drug. Coordinate specialty pharmacy, prior auth, and nurse visits yourself. Remember to schedule your next dose six months out.
With Instalab
Physician review within one business day. Mobile nurse comes to you — we handle scheduling. Renewals and lab rechecks tracked automatically.
About the medication
Two visits in the first three months. Then twice a year.
Leqvio comes pre-filled in a single-dose syringe. A licensed nurse administers it as a subcutaneous injection. The injection itself takes seconds, and you can keep your day moving.
- Administered by a mobile nurseA licensed nurse comes to your home or office. No clinic visits, no infusion center. The injection itself takes seconds.
- Twice yearly after the loading phaseDay 0, month 3, then every 6 months. Two visits a year is enough to keep LDL and ApoB consistently low.
- Lab recheck at 8 weeksRecheck LDL and ApoB around 8 weeks so you can see your progress. Maximum effect appears after the second dose. Labs are billed separately.
- Ongoing physician oversightYour membership physician follows your labs over time and adjusts the broader plan as your numbers evolve.
Why Leqvio
Different mechanism. Twice-yearly dosing.
Statins slow cholesterol production. Antibody PCSK9 inhibitors mop up the protein in circulation. Leqvio takes a different path: it silences PCSK9 mRNA inside the liver, so the protein is never made in the first place. The effect is durable enough that two injections a year is enough to keep LDL and ApoB cut in half.
- Clinically proven ~50% LDL and ApoB reductionAcross the ORION-9, ORION-10, and ORION-11 trials with thousands of patients, Leqvio cut LDL by roughly half on top of or instead of a statin, with comparable reductions in ApoB.
- A mechanism statins and antibodies cannot replicateLeqvio uses RNA interference to break down PCSK9 mRNA inside liver cells. Less PCSK9 means more LDL receptors stay active and pull more LDL out of your blood.
- Twice a year, not twice a monthAfter two starter doses, one injection every six months keeps LDL low. No daily pill, no biweekly self-injection — just two nurse visits a year.
The ORION trials
Published in NEJM in 2020, the ORION-10 and ORION-11 trials randomized over 3,000 patients with atherosclerotic cardiovascular disease or risk-equivalents to inclisiran or placebo on top of maximally tolerated statin therapy. Across both trials, inclisiran reduced LDL by roughly 50% and ApoB by 40–50% at 17 months. Pooled analyses also suggest a meaningful reduction in cardiovascular events, with larger outcome trials still ongoing.
3,178
Patients randomized (ORION-10/11)
~50%
LDL reduction at month 17
~25%
Reduction in major cardiovascular events (pooled)
Real results
What twice-yearly dosing looks like in practice.
Three patients, 8 to 14 weeks after their first injection.
14261LDL mg/dL8 weeks after first injection
“I'd been on max-dose rosuvastatin plus ezetimibe for two years and still couldn't get under 130. The first injection cut my LDL in half. I made the lab run it twice.”
16878LDL mg/dL12 weeks, after second loading dose
“I kept forgetting my Repatha pens. They'd sit in the fridge for weeks at a time. Two shots a year is the only schedule I can actually keep.”
21196LDL mg/dL14 weeks after first injection
“Very high cholesterol runs in my family. My dad had a heart attack at 51. Having a nurse come to my office made it possible to actually start treatment instead of putting it off another year.”
Leqvio is a prescription medicine. Important safety information applies. The most common side effects are mild injection-site reactions and short-lived flu-like symptoms. Serious side effects are uncommon.
Common Questions
Everything people ask before starting.
Ready when you are
See if Leqvio is right for you in two minutes.
Answer a few questions and upload a recent lab result. A board-certified lipidologist reviews your case and, if appropriate, prescribes Leqvio. We schedule the mobile nurse visit and track your labs from there.
No commitment to treatment.