From order to insights in three easy steps — no doctor’s visit required.
1
Order + Activate Test
Your collection kit is shipped directly to your home. Activate it online before beginning.
2
Drink Solution + Collect Urine
After consuming a sugar solution, collect a urine sample over 6 hours following the easy instructions provided. Return your specimen with prepaid shipping materials.
3
Receive Results + Report
Results are available within 2–3 weeks. You’ll receive a detailed report with interpretation and recommendations.
Is This Right for You?
This test is designed for people who
If any of these apply, this test can give you clarity and peace of mind.
Suspect leaky gut may be behind chronic bloating, food sensitivities, or widespread inflammation
Have an autoimmune condition and want to test whether intestinal permeability is a contributing factor
Deal with skin issues, joint pain, or brain fog that seem connected to what you eat
Have tried gut protocols or dietary changes and want a measurable way to confirm your gut lining is healing
Want a specific, clinical assessment of leaky gut rather than relying on symptoms alone
Prefer a simple at-home urine collection with a detailed report and clear next steps for gut repair
3 key biomarkers
What's included in your report
Each result will include your value, your personalized optimal range, and a plain-language interpretation.
Mannitol
A small sugar molecule that is normally absorbed through the intestinal lining. Measuring mannitol in urine reflects how well the gut takes up nutrients. Low recovery can signal poor absorption or damage to the intestinal surface.
Lactulose
A large molecule that is usually blocked by a healthy intestinal barrier. Finding high levels in urine suggests increased permeability, often called “leaky gut”, where larger, unwanted molecules slip through.
Lactulose/Mannitol Ratio
The key marker of barrier function. A balanced ratio means normal absorption and protection. A high ratio points to excessive permeability, while a low ratio indicates impaired absorption.
Common Questions
Frequently asked questions
What is the Intestinal Permeability Test?
What does “intestinal permeability” mean?
Who should consider the Intestinal Permeability Test?
How accurate is the Intestinal Permeability Test?
Do I need to fast before the Intestinal Permeability Test?
What exactly is measured in the Intestinal Permeability Test?
Can I take probiotics, supplements, or medications before the Intestinal Permeability Test?
How is the Intestinal Permeability Test performed?
How long does it take to get results for the Intestinal Permeability Test?
What can my results show for the Intestinal Permeability Test?
Is the Intestinal Permeability Test the same as colon cancer screening?
How does the Intestinal Permeability Test compare to a stool test?
How often should I repeat the Intestinal Permeability Test?
Where is my sample processed for the Intestinal Permeability Test?
Will my insurance cover the Intestinal Permeability Test?
Can the Intestinal Permeability Test detect food sensitivities?
What if I’m menstruating during collection for the Intestinal Permeability Test?
What if I miss part of the urine collection period for the Intestinal Permeability Test?
How should I store my sample before sending it for the Intestinal Permeability Test?
Does the Intestinal Permeability Test check for SIBO (Small Intestinal Bacterial Overgrowth)?
Instalab
