2-minute questionnaire
Tell us about your statin history, current LDL, and target. Whether you want ezetimibe as an add-on or a non-statin standalone.
InstalabEzetimibe · 10mg · generic Zetia®
15 to 25% more LDL reduction. Without another statin.
Ezetimibe (generic Zetia®) blocks cholesterol absorption for an extra 15–25% LDL drop. $49 online visit, no Instalab+ needed. Pay your pharmacy directly for the medication.
10mgOnce daily
Non-statinDifferent mechanism
15–25%LDL reduction, solo or combo
Ezetimibe 10mg · once daily · food-independent
Licensed US physician review
12,000+ patients treated
Available in all 50 states
Sent to your pharmacy
How it works
From questionnaire to first dose.
A 2-minute questionnaire, a $49 online visit, and your prescription sent to the pharmacy you choose. The visit is a physician review of your answers: no appointments, no calls, no Instalab+ needed.
$49 online visit
A licensed physician reviews your health history and determines whether ezetimibe is appropriate for your lipid profile, usually within 1 business day.
Sent to your pharmacy
If approved, we send the prescription to your preferred pharmacy,. You pay the pharmacy directly, usually just a few dollars a month.
Lipid recheck at 4 to 12 weeks
Most of the LDL drop shows up in the first two weeks. Recheck lipids at 4 to 12 weeks to confirm your response and adjust if needed.
Pricing
What you'll actually pay.
Two line items: a one-time online visit and the ezetimibe itself, dispensed by your pharmacy. No Instalab+ needed.
Online Visit
One-time physician review of your health history, with follow-up support included
$49one-time
Ezetimibe 10mg
Generic, dispensed by your pharmacy
Cash price$5–16/monthTypical pharmacy cash price
With insurance$0–10/monthTypical copay, if covered
The online visit is a one-time fee, not a subscription. It covers a physician review of your health history and, if the physician determines treatment is appropriate, a prescription with refills for up to one year, sent to the pharmacy you choose. If no prescription is issued, the $49 fee is refunded. You pay the pharmacy directly for the medication. Renewing after a year takes a new online visit; dose changes require Instalab+, which never charges visit fees.
Need more than ezetimibe alone?
Combination therapy with physician oversight.
If your LDL or ApoB is still above target on ezetimibe, the usual next step is adding a statin or another lipid-lowering therapy. Instalab+ includes the physician consults and lab follow-up that combination therapy requires.
Instalab+ also covers online visits, so treatment changes and renewals never cost extra.
Explore Instalab+ →About the medication
A simple daily routine, backed by data.
One small pill, once a day. Most patients see measurable LDL reduction within a few days, with steady-state effect by about week two.
- Take once dailyAny time of day, with or without food. Pick a time that fits your routine and stay consistent.
- No titration requiredOne 10mg dose works for everyone. No dose escalation, no timing tricks.
- Works on its own or with a statinEzetimibe lowers LDL by about 15 to 20% on its own. Added on top of a statin, it drops LDL another 25%. The 2018 ACC/AHA guidelines name it as the first-line non-statin add-on when a statin alone isn't enough.
- Recheck lipids at 4 to 12 weeksWe recommend a follow-up lab at 4 to 12 weeks to confirm your response, even though most of the LDL drop shows up within the first two weeks.
Why ezetimibe
The first non-statin add-on proven to cut cardiovascular events.
Ezetimibe selectively blocks the NPC1L1 transporter in the small intestine, the protein that pulls dietary and biliary cholesterol into the body. Blocking it means less cholesterol reaches the liver, so the liver pulls more LDL out of the bloodstream. It's mechanistically distinct from statins, which is why it can meaningfully lower LDL on its own and why combining the two works even better.
- Works on its ownAs monotherapy, ezetimibe lowers LDL by roughly 15 to 20%, a meaningful drop without a statin. It's a real option for people who can't tolerate statins or prefer to start with a non-statin.
- Even stronger with a statinAdded on top of a statin, ezetimibe cuts LDL by another 25%. IMPROVE-IT proved that combination further reduces heart attacks and strokes in high-risk patients, validating the "lower LDL is better" principle.
- A different target, gentler profileEzetimibe works in the gut, not the liver, and side effects as monotherapy are comparable to placebo. No titration, no timing tricks, one 10mg tablet a day.
The IMPROVE-IT trial
Published in NEJM in 2015, IMPROVE-IT followed 18,144 post-heart-attack patients for six years. Half took a statin alone; half took the same statin plus ezetimibe. The combination group had lower LDL and fewer cardiovascular events. It was the first trial to prove a non-statin add-on cuts event risk, validating the principle that lower LDL is better.
18,144
Post-ACS patients enrolled
54 vs 70
Mean LDL, combo vs statin alone (mg/dL)
~2%
Absolute CV event reduction at 6 years
Real results
What ezetimibe looks like in practice.
Three patients, eight to ten weeks in.
152124LDL mg/dL10 weeks on 10mg
“Statins gave me muscle pain I couldn't shake. Ezetimibe on its own knocked almost 30 points off my LDL with none of the aches.”
142118LDL mg/dL8 weeks on 10mg
“I wanted a lower-LDL strategy that wasn't a statin. One pill a day, no side effects, and a solid drop in my numbers.”
14248LDL mg/dL8 weeks on 10mg
“My statin got me most of the way. Adding ezetimibe took another 40 points off and finally got me under 70.”
Ezetimibe is a prescription medicine. Important safety information applies. Common side effects include upper respiratory symptoms, diarrhea, and joint pain.
Common Questions
Everything people ask before starting.
Ready when you are
Lower LDL without another statin.
Answer the questionnaire. A physician reviews your case, and if ezetimibe is appropriate, your prescription goes out.
No commitment to treatment.