2-minute questionnaire
Answer questions about your history, prior cholesterol treatments, and cardiovascular goals. No appointment needed.
InstalabLipfendra · 20mg · enlicitide tablet
One pill each morning. LDL cut by more than half.
Lipfendra (enlicitide) is the first oral PCSK9 inhibitor: the LDL-lowering power of injectables like Repatha in a once-daily tablet. It cuts LDL by 56–59% on top of a statin. Prescription, refills, and physician follow-up included.
Lipfendra was FDA-approved in July 2026, but it is not yet available. Leave your email and we will notify you the moment you can start an eligibility check and get started.
56–59%LDL reduction on top of a statin
1 pillOnce daily, no injections
~50%ApoB reduction
Lipfendra 20mg · once-daily tablet · morning, before eating
Licensed US physician review
12,000+ patients treated
Available in all 50 states
Ongoing physician follow-up
How it works
From questionnaire to first tablet.
No appointments. No clinic visits. A licensed physician reviews your case, checks what you'll pay, and, if appropriate, sends the prescription to your pharmacy.
Physician review
A licensed physician evaluates your eligibility, usually within 1 business day, and reaches out if they need anything else.
Cost check
Lipfendra is newly approved, so coverage is still rolling out plan by plan. We check your insurance, file prior authorization if your plan covers it, and apply Merck's savings program if you're eligible. You see your monthly cost before you commit.
Prescription sent, first dose
Your prescription goes to your preferred pharmacy. Take your first tablet the next morning before eating, and we'll check in after your first week.
Pricing
What you'll actually pay.
Two line items: Instalab+ and the Lipfendra medication itself. No hidden fees.
Instalab+
Physician oversight and ongoing follow-up
$—/mo
Lipfendra 20mg
Enlicitide tablets, 30-day supply, billed by pharmacy
Cash price$315/moMerck list price
With insuranceVariesCoverage rolling out; we check your plan
Why pay a monthly fee? Lipfendra is brand new, and getting it covered takes a physician who knows the drug and the paperwork. Instalab+ covers the visits, prescription renewals, prior authorization, and savings-program enrollment. We also recommend a lab recheck around 4 to 8 weeks and follow up on your results, though lab costs are billed separately.
Will my insurance cover Lipfendra?
Lipfendra was approved in July 2026, so formulary decisions are still rolling out. Most plans are expected to handle it like the injectable PCSK9 inhibitors: coverage if you have familial hypercholesterolemia, established cardiovascular disease, or documented statin intolerance, usually after a documented statin trial. We check your plan and file the prior authorization either way. Merck has announced a savings program for eligible commercially insured patients, and the $315/month list price is about half that of the injectable PCSK9 options.
Why Instalab+
Lipfendra works. Staying on it takes ongoing care.
A brand-new drug needs a physician who knows it, paperwork handled, and labs to confirm it's doing its job. Here's how our team handles that for you.
- Week 1Day 1–5
Physician evaluation and prescription
A licensed physician reviews your history and labs, confirms Lipfendra is right for you, and writes the prescription. In parallel, we verify your insurance coverage, file prior authorization, and check your eligibility for Merck's savings program. If you'd rather pay cash, this takes as little as one day.
- Week 2Day 6–14
First tablet at home
Your prescription can be picked up at or delivered by your preferred pharmacy. We walk you through the morning routine that makes it work: one tablet before eating, then wait 30 minutes. We check in after your first week.
- Week 4–8
Confirm it's working
The LDL-lowering effect is measurable as early as 4 weeks. We recommend rechecking LDL and ApoB at a lab near you, and your physician reviews the results with you. Labs are billed separately. Rechecking is optional, but most patients want to see their numbers move.
- OngoingMonth 3+
Ongoing care and renewals
Your physician tracks your labs over time and adjusts the plan as your numbers evolve. We keep your prescription, prior authorization, and savings enrollment active, so you don't lose progress to paperwork.
Without Instalab+
Schedule a PCP visit. Wait months. Hope they've heard of a drug approved this year. Fight the prior authorization yourself. Book and chase your own labs.
With Instalab+
2-minute questionnaire. Physician review within 1 business day. Insurance and savings program handled. Lab reminders built in.
About the medication
One tablet. Every morning. Before breakfast.
Lipfendra is a once-daily tablet taken in the morning on an empty stomach with water, black coffee, or plain tea. Wait 30 minutes before eating or drinking anything else; that one habit is what makes an oral PCSK9 inhibitor possible.
- Just a pill, once a dayNo injections, no refrigeration, no sharps container. Swallow the tablet whole each morning. It travels in your bag at room temperature.
- The 30-minute ruleTake it on an empty stomach with water, black coffee, or plain tea, then wait at least 30 minutes before eating. Taking it too soon after food cuts absorption roughly in half.
- Lab recheck recommendedWe recommend rechecking LDL and ApoB around 4 to 8 weeks so you can see your progress. Labs are optional and billed separately.
- Ongoing physician supportYour care team is a message away, and your Instalab+ physician follows your labs over time. Missed a dose? Take it when you remember that day; never double up.
Why Lipfendra
PCSK9 inhibition, finally in a pill.
Statins slow cholesterol production in the liver. PCSK9 inhibitors take a different path: they block the protein that destroys LDL receptors, so your liver keeps clearing LDL from your blood. Until now that meant injections (Repatha, Praluent) or an infusion schedule (Leqvio). Lipfendra reaches the same target with a once-daily tablet.
- 56–59% LDL reduction on top of a statinIn two 52-week placebo-controlled trials in patients already on statins, Lipfendra 20mg lowered LDL by about 56% in hypercholesterolemia and 59% in familial hypercholesterolemia, with roughly 50% reductions in ApoB and non-HDL cholesterol.
- Who Lipfendra is forAdults whose LDL or ApoB stays too high on a statin, who can't tolerate a statin, or who have familial hypercholesterolemia. It works alongside a statin or on its own. If injectable PCSK9 inhibitors were ever suggested to you, this is the same drug target in pill form.
- The first oral PCSK9 inhibitorEnlicitide is a macrocyclic peptide, a molecule small enough to formulate as a tablet but precise enough to block PCSK9 like an antibody does. Injectable potency, without the injection.
- No meaningful drug interactionsLipfendra did not meaningfully change blood levels of warfarin, atorvastatin, levothyroxine, digoxin, lithium, lisinopril, or oral semaglutide in interaction studies. You can take it alongside your other medications.
The CORALreef trials
Two 52-week placebo-controlled Phase 3 trials studied enlicitide 20mg once daily in adults already on statin therapy. CORALreef Lipids, in hypercholesterolemia, showed about 56% placebo-adjusted LDL reduction; CORALreef HeFH, in heterozygous familial hypercholesterolemia, showed about 59%, with roughly 50% reductions in ApoB and non-HDL cholesterol. Side effects occurred about as often as with placebo. FDA approval followed in July 2026. A dedicated cardiovascular outcomes trial (CORALreef Outcomes) is ongoing; outcomes trials of statins and injectable PCSK9 inhibitors have shown that lowering LDL this way reduces heart attacks and strokes.
56–59%
Placebo-adjusted LDL reduction
52 wks
Trial duration
~50%
ApoB reduction
Lipfendra is a prescription medicine. Important safety information applies. In clinical trials, side effects occurred about as often as with placebo; the most common in familial hypercholesterolemia patients were diarrhea and dizziness. Serious side effects are uncommon.
Ready when you are
See if Lipfendra is right for you
Answer a few questions about your history and goals. A physician reviews your case and, if appropriate, prescribes Lipfendra.
No commitment to treatment.