2-minute questionnaire
Tell us your current lipids, family history, and statin history. We ask the same questions a cardiologist would.
InstalabRosuvastatin · 5mg · generic Crestor®
41% LDL reduction at the gentlest dose.
The most-studied statin, at its gentlest dose. Rosuvastatin (generic Crestor®) drops LDL 41% at just 5mg. $49 online visit, no Instalab+ needed. Pay your pharmacy directly for the medication.
5mgOnce daily
JUPITEROutcome-validated trial
41%Avg LDL drop at 5mg
Rosuvastatin 5mg · once daily · food-independent
Licensed US physician review
12,000+ patients treated
Available in all 50 states
Sent to your pharmacy
How it works
From questionnaire to first dose.
A 2-minute questionnaire, a $49 online visit, and your prescription sent to the pharmacy you choose. The visit is a physician review of your answers: no appointments, no calls, no Instalab+ needed.
$49 online visit
A licensed physician reviews your health history and determines whether 5mg rosuvastatin is appropriate based on your LDL and risk profile, usually within 1 business day.
Sent to your pharmacy
If approved, we send the prescription to your preferred pharmacy,. You pay the pharmacy directly, usually just a few dollars a month.
LDL recheck at 6 to 8 weeks
Most of the LDL drop lands by week 6 to 8. Recheck your lipids then to confirm your response and decide if 5mg is enough.
Pricing
What you'll actually pay.
Two line items: a one-time online visit and the rosuvastatin itself, dispensed by your pharmacy. No Instalab+ needed.
Online Visit
One-time physician review of your health history, with follow-up support included
$49one-time
Rosuvastatin 5mg
Generic, dispensed by your pharmacy
Cash price$4–15/monthTypical pharmacy cash price
With insurance$0–10/monthTypical copay, if covered
The online visit is a one-time fee, not a subscription. It covers a physician review of your health history and, if the physician determines treatment is appropriate, a prescription with refills for up to one year, sent to the pharmacy you choose. If no prescription is issued, the $49 fee is refunded. You pay the pharmacy directly for the medication. Renewing after a year takes a new online visit; dose changes require Instalab+, which never charges visit fees.
Need more than 5mg?
Titrate up to 40mg with physician oversight.
For patients aiming for LDL well below 70 — familial hypercholesterolemia, established cardiovascular disease, or aggressive primary prevention. Instalab+ includes the physician consults and lab follow-up that higher doses require.
Step up to 10mg, 20mg, or 40mg as your labs evolve. Same drug, same routine — your physician adjusts the dose based on your numbers, not yours alone.
Instalab+ also covers online visits, so dose changes and renewals never cost extra.
Explore Instalab+ →Doses available
5mg is where most people should start.
It's the gentlest effective dose of rosuvastatin, and for most people, it's enough. A ~41% LDL reduction is usually sufficient to hit target.
If your labs eventually call for a higher dose, Instalab+ includes the physician oversight that higher doses require.
5 mg Available to everyone
Gentle entry dose · lowest side-effect profile · ~41% avg LDL reduction
$49 online visit
Higher doses carry higher side-effect risk and require more frequent lab monitoring. We don't sell them self-serve. That care belongs inside Instalab+ with physician follow-up.
About the medication
A simple daily routine, backed by data.
One small pill, once a day. Most patients see measurable LDL and ApoB reduction within 6–8 weeks.
- One pill, once a dayTake it at the same time each day, with or without food.
- Consistent daily routineMost patients take it in the evening. Pick a time that works and stick with it.
- Lab monitoring recommendedWe'll recommend follow-up labs at 6–8 weeks so you can see your progress.
- Ongoing supportOur care team is a message away. We check in after you start.
Why rosuvastatin
More evidence than any other statin.
Rosuvastatin is a high-intensity statin that blocks the liver enzyme your body uses to make cholesterol. Milligram-for-milligram, it's more potent than any other statin on the market, which is why even 5mg delivers a meaningful LDL drop for most people.
- Proven in the largest statin trial ever runThe JUPITER trial followed 17,802 patients over nearly two years and showed rosuvastatin cut major cardiovascular events by 44%. Most statin guidelines today reference this evidence.
- The shortest milligram ladder in statinsRosuvastatin comes in 5, 10, 20, and 40mg, a clean dose progression. Atorvastatin jumps from 10 to 80; simvastatin tops out at 40. The tighter ladder means smaller adjustments when your labs call for them.
- Gentle on the liver, kind to the routineRosuvastatin has a long half-life of about 19 hours, so missing a dose is forgiving, and it's cleared by the liver with minimal drug interactions. One small pill, any time of day, with or without food.
The JUPITER trial
Published in NEJM in 2008, JUPITER randomized 17,802 adults with normal LDL but elevated inflammation (hsCRP) to rosuvastatin 20mg or placebo. The trial stopped early after a median 1.9 years because the benefit was so clear: rosuvastatin cut major cardiovascular events by 44% and all-cause mortality by 20%, establishing it as one of the most outcome-validated statins in modern cardiology.
17,802
Adults randomized
44%
Relative reduction in major CV events
20%
Reduction in all-cause mortality
Same LDL drop. Very different
| LDL reduction target | Rosuvastatin | Atorvastatin | Simvastatin |
|---|---|---|---|
~41% Moderate intensity | 5 mg this page | 20 mg | 40 mg |
~46% Moderate to high | 10 mg | 40 mg | 80 mg |
~50 to 55% High intensity | 20 to 40 mg | 80 mg | — |
Real results
What 5mg looks like in practice.
Three patients, six weeks in.
16598LDL mg/dL8 weeks on 5mg
“I put off a statin for years. Starting at 5mg felt low-stakes. Eight weeks in, my LDL dropped 40 percent.”
12268LDL mg/dL8 weeks on 5mg
“My family history pushed me to want LDL well under 70. 5mg got me there in two months, no side effects.”
172109LDL mg/dL8 weeks on 5mg
“Atorvastatin wrecked my calves. 5mg rosuvastatin, no muscle symptoms, and my LDL still dropped about a third.”
Rosuvastatin is a prescription medicine. Important safety information applies. Common side effects include muscle aches, headache, and nausea.
Common Questions
Everything people ask before starting.
Ready when you are
Cut LDL 41% at the gentlest dose.
Answer the questionnaire. A physician reviews your case. If 5mg rosuvastatin is appropriate, your prescription goes out.
No commitment to treatment.