Know your inherited neurodegeneration risk before symptoms appear

Alzheimer's disease

Genes linked to inherited Alzheimer's disease. PSEN1 and PSEN2 cause rare early-onset forms, while APOE affects risk for the more common late-onset form.

Parkinson's disease

Genes tied to typical-onset Parkinson's disease. LRRK2 and GBA are the most common genetic risk factors and are actively being targeted by new therapies.

Young-onset Parkinson's & parkinsonism

Genes behind Parkinson's that starts before age 50. These tend to be recessive (inherited from both parents) and often progress more slowly.

Frontotemporal dementia & ALS overlap

Genes behind frontotemporal dementia (FTD), which affects personality and language. C9orf72 can cause both FTD and ALS in the same family.

Rare movement & dystonia disorders

Genes causing inherited dystonia and movement disorders. Some, like GCH1, respond very well to medication when diagnosed.

Rare inherited dementias

Genes behind rare forms of inherited dementia, including prion disease, CADASIL (small vessel strokes), and white matter disorders.