Hypophosphatemic Rickets Genetic Test

Understand the genetic roots of rickets and bone softening disorders

A comprehensive DNA test that screens 22 genes for inherited phosphate wasting, vitamin D metabolism defects, kidney tubular disorders, and bone mineralization conditions.

$499$600Save $101

HSA / FSA eligible

Free shippingSpecimen:Buccal swabCollection:SelfCLIA-certified lab:FulgentResults:2-3 weeks

Simple Process

How it works

From order to insights in three easy steps — no doctor’s visit required.

Get Your Collection Kit

Your kit will arrive in about of a week of purchase. It includes everything you need to collect your DNA.

Collect Your Sample

You'll swab the inside of your mouth with the provided buccal swab. That's it. Send it back using the prepaid shipping label.

Receive Your Results

Results will be ready within 2-3 weeks after your sample arrives at the lab. You'll receive a detailed report with your results.

Is This Right for You?

This test is designed for people who

If any of these apply, this test can give you clarity and peace of mind.

Have a family history of rickets, osteomalacia, or unexplained bone softening disorders

Want to understand whether they carry inherited gene variants that affect phosphate or vitamin D metabolism

Have been diagnosed with low phosphate levels, bowed legs, bone pain, or frequent fractures without clear cause

Have rickets or osteomalacia that doesn’t respond to standard vitamin D supplementation

Are planning a family and want to know about inherited bone or kidney conditions they could pass on

Have been referred by an endocrinologist, nephrologist, or geneticist for hereditary phosphate or bone disorder screening

22 Genes · 4 Categories

What your report covers

Each category is reviewed by a board-certified geneticist and mapped to clinical guidelines.

Phosphate wasting disorders

Genes that cause the kidneys to lose too much phosphate, leading to soft or bowed bones. PHEX is the most common cause of inherited rickets.

Vitamin D metabolism & response

Genes needed to activate or respond to vitamin D. Defects cause rickets that may or may not respond to standard vitamin D supplements.

Kidney tubular disorders

Genes behind kidney tubule disorders that leak phosphate along with other minerals. Rickets is one feature of broader kidney or metabolic conditions.

Bone mineralization defects

Genes that directly affect how minerals are deposited into bone. ALPL deficiency (hypophosphatasia) mimics rickets but has a different treatment approach.

Trusted by Thousands

What customers say

Real results from real people taking control of their bone health.

★★★★★

“Finally understood why my bones never healed right”

I’d had stress fractures since my teens and chronically low phosphate levels that no one could explain. This test found a PHEX variant linked to X-linked hypophosphatemic rickets. My endocrinologist started me on burosumab and for the first time in years my bones are actually getting stronger.

Laura M.34

★★★★★

“Vitamin D supplements never worked until I knew why”

I took high-dose vitamin D for years but my levels stayed low and my joints kept aching. This test revealed a CYP27B1 variant, which means my body can’t activate vitamin D on its own. My doctor switched me to calcitriol and the difference has been night and day.

James T.47

★★★★★

“Stopped guessing and got a real diagnosis”

I was told I had "just low vitamin D" for years, but supplements never fixed my bone pain or fatigue. This test identified an SLC34A3 variant causing hereditary hypophosphatemic rickets. Now I’m on the right treatment and actually feeling better.

Priya S.29

Take the first step for your bone health

Know your genetic risks. Share with your doctor. Build a stronger treatment plan.

Hypophosphatemic Rickets Genetic Test

Understand the genetic roots of rickets and bone softening disorders

A comprehensive DNA test that screens 22 genes for inherited phosphate wasting, vitamin D metabolism defects, kidney tubular disorders, and bone mineralization conditions.

$499$600Save $101

HSA / FSA eligible

Free shippingSpecimen:Buccal swabCollection:SelfCLIA-certified lab:FulgentResults:2-3 weeks

Simple Process

How it works

From order to insights in three easy steps — no doctor’s visit required.

Get Your Collection Kit

Your kit will arrive in about of a week of purchase. It includes everything you need to collect your DNA.

Collect Your Sample

You'll swab the inside of your mouth with the provided buccal swab. That's it. Send it back using the prepaid shipping label.

Receive Your Results

Results will be ready within 2-3 weeks after your sample arrives at the lab. You'll receive a detailed report with your results.

Is This Right for You?

This test is designed for people who

If any of these apply, this test can give you clarity and peace of mind.

Have a family history of rickets, osteomalacia, or unexplained bone softening disorders

Want to understand whether they carry inherited gene variants that affect phosphate or vitamin D metabolism

Have been diagnosed with low phosphate levels, bowed legs, bone pain, or frequent fractures without clear cause

Have rickets or osteomalacia that doesn’t respond to standard vitamin D supplementation

Are planning a family and want to know about inherited bone or kidney conditions they could pass on

Have been referred by an endocrinologist, nephrologist, or geneticist for hereditary phosphate or bone disorder screening

22 Genes · 4 Categories

What your report covers

Each category is reviewed by a board-certified geneticist and mapped to clinical guidelines.

Phosphate wasting disorders

Genes that cause the kidneys to lose too much phosphate, leading to soft or bowed bones. PHEX is the most common cause of inherited rickets.

Vitamin D metabolism & response

Genes needed to activate or respond to vitamin D. Defects cause rickets that may or may not respond to standard vitamin D supplements.

Kidney tubular disorders

Genes behind kidney tubule disorders that leak phosphate along with other minerals. Rickets is one feature of broader kidney or metabolic conditions.

Bone mineralization defects

Genes that directly affect how minerals are deposited into bone. ALPL deficiency (hypophosphatasia) mimics rickets but has a different treatment approach.

Trusted by Thousands

What customers say

Real results from real people taking control of their bone health.

★★★★★

“Finally understood why my bones never healed right”

Laura M.34

★★★★★

“Vitamin D supplements never worked until I knew why”

James T.47

★★★★★

“Stopped guessing and got a real diagnosis”

Priya S.29

Take the first step for your bone health

Know your genetic risks. Share with your doctor. Build a stronger treatment plan.