Copper Bisglycinate 2000 mcg by Thorne

If you’re searching for copper bisglycinate because your Serum Copper or Ceruloplasmin (the main copper-carrying protein) is low, this is the right lane. It’s useful after high zinc intake (zinc lozenges, denture creams, or >25–30 mg/day zinc supplements), after bariatric surgery, or with malabsorption like celiac or inflammatory bowel disease. Unexplained anemia and low white cells on a CBC can also stem from low copper. Vegans rarely need extra if labs are normal, and anyone with established deficiency will usually need a repletion plan, then step down.

Copper bisglycinate is copper chelated to the amino acid glycine, which tends to absorb well and is gentler on the stomach than copper oxide or sulfate. Copper is a cofactor for cytochrome c oxidase (a key enzyme for cellular energy), lysyl oxidase (collagen cross-linking for connective tissue), and superoxide dismutase (an antioxidant enzyme that neutralizes free radicals). It also enables ceruloplasmin’s ferroxidase activity, which helps move iron, so low copper can look like iron-deficiency anemia that doesn’t fully respond to iron.

Each capsule supplies 2 mg of copper. The suggested use is 1 capsule one to three times daily, typically with food if you’re prone to nausea. For maintenance when labs are low-normal, once daily is common; for documented deficiency, clinicians often use higher total daily amounts for a short period, then taper. Separate from zinc or iron by at least two hours so they don’t compete for absorption. Re-check Serum Copper and Ceruloplasmin within 4–8 weeks; blood counts often lag and normalize over 8–12 weeks.

Avoid copper supplements if you have Wilson’s disease (a genetic copper-overload condition) or unexplained elevated Serum Copper. Use caution with chronic liver disease unless your clinician is guiding therapy. Penicillamine and tetrathiomolybdate bind copper and will counteract it. If you take high-dose zinc long term, balance matters—either lower the zinc or add copper under supervision rather than guessing. Pregnancy and pediatrics: supplement only if labs are low and your clinician agrees.

Is copper bisglycinate better absorbed than copper sulfate? In practice it’s well tolerated and reliably absorbed, especially if standard salts upset your stomach. How fast will I feel a difference? Energy and skin changes are subtle; the real readout is labs—Serum Copper and Ceruloplasmin shift within weeks. Can copper upset my stomach? It can; taking with food and avoiding co-administration with zinc or iron usually fixes it.