PolyResveratrol-SR by Thorne

People working on metabolic labs often look past red wine to a resveratrol supplement. This sustained‑release blend fits adults tracking hs-CRP (an inflammation marker) or fasting insulin who want a non‑caffeinated polyphenol stack. It’s also a reasonable pick if you rarely eat richly colored plants, avoid alcohol, or want pterostilbene (a close cousin of resveratrol) without taking it separately. If your numbers are already excellent, expect subtle effects, not a life extension pill.

Resveratrol and pterostilbene nudge AMPK (the cell’s fuel gauge that shifts you toward burning fat and improving insulin handling) and damp NF‑κB (a gene switch that drives inflammatory signaling). Curcumin, green tea (decaffeinated EGCG), and quercetin layer on additional anti‑inflammatory and antioxidant activity. All five are in phytosome form, meaning they’re bound to phospholipids to improve absorption. The sustained‑release matrix smooths peaks and valleys, which many find gentler on the stomach and more consistent across the day.

Take 2 capsules once or twice daily with a meal, as the manufacturer suggests. Food improves tolerance and helps fat‑soluble curcumin absorb. If your goal is metabolic change, give it 8–12 weeks, then recheck hs-CRP and fasting insulin; some also track ALT (a liver enzyme) and Triglycerides. Separate from iron supplements by two hours because polyphenols can reduce iron absorption. Consistency matters more than time of day.

Avoid if you use blood thinners or antiplatelets (warfarin, apixaban, rivaroxaban, aspirin, clopidogrel) unless your clinician agrees, due to additive bleeding risk. Use caution with drugs cleared by CYP enzymes or transporters (the liver and gut systems that move many drugs), including cyclosporine, tacrolimus, some chemotherapy, and certain blood pressure meds. History of gallstones or bile duct blockage is a reason to avoid curcumin blends. Past liver injury from green tea extracts warrants baseline and follow‑up liver tests. Not for pregnancy or breastfeeding.