Stress Balance by Thorne

Busy adults with rising work stress who want a gentle adaptogen supplement for stress tend to like this blend. If your morning cortisol (the stress hormone measured in blood or saliva) runs high, or your DHEA-S (an adrenal hormone that often falls with chronic stress) is on the low side, this is a maintenance-level option. It’s also reasonable if caffeine makes you edgy and you want steadier daytime energy without stimulants. If your stress or fatigue is severe, a higher-dose single adaptogen like ashwagandha 300–600 mg or rhodiola 200–400 mg is usually a better first step.

Ashwagandha can lower perceived stress and modestly reduce cortisol by tuning the HPA axis (the brain–adrenal control loop). Panax ginseng and eleuthero nudge mental and physical stamina without the jitter of caffeine. Licorice slows the enzyme that breaks down cortisol, extending its effect, which helps some people with afternoon energy dips but can raise blood pressure in sensitive patients. Astragalus is an immune-leaning tonic, while vitamins B1, B5, and B6 plus vitamin C and zinc replenish nutrients the adrenals use during chronic stress. The doses here are moderate, aiming for steadying rather than a dramatic effect.

Take two capsules with breakfast, and add a second two-capsule dose at lunch on heavier days. Avoid late evening use because ginseng can be stimulating for some. Most people notice smoother energy and less reactivity within 2 to 4 weeks; if you track morning cortisol or a salivary cortisol curve, recheck after 6 to 8 weeks. If you need more intensity, pair with a standalone ashwagandha or rhodiola rather than exceeding the suggested use.

Skip this if you have uncontrolled high blood pressure, chronic low potassium, kidney disease, or are pregnant or breastfeeding—the licorice content is the reason. Use caution with thyroid disease or if you take thyroid medication, because ashwagandha can shift thyroid labs. If you’re on warfarin, insulin or diabetes drugs, or corticosteroids, talk to your clinician; ginseng and licorice can alter blood thinning, blood sugar, and cortisol metabolism. If you’ve had unexplained liver issues, avoid multi-herb formulas and choose a single-ingredient approach.