DHEA-S Test

DHEA sulfate is a stable storage form of DHEA produced primarily by the adrenal glands. It serves as a precursor for both estrogen and testosterone and plays a role in immune regulation, mitochondrial function, and stress adaptation. Levels peak in early adulthood and decline progressively with age, making it a marker of biological aging rather than acute stress. Chronically low levels are associated with frailty, reduced stress tolerance, and poor recovery, while elevated levels may reflect supplementation or adrenal hyperactivity. Interpretation requires age and sex context.