Ezetimibe blocks cholesterol absorption in the gut, helping reduce ApoB and LDL cholesterol beyond what diet or statins alone can achieve.
Ezetimibe can lower ApoB and LDL by 17-21% on its own and boost statin effects by an additional 15-25%, with one of the best tolerability profiles available.
Your prescription is evaluated and approved by a board-certified lipidologist same day. This ensures this medication is safe for you.
Your medication is filled through licensed U.S. pharmacies that follow strict protocols for quality, consistency, and safety, so every tablet meets the highest standard.
Ezetimibe reduces ApoB and LDL cholesterol by 17-21% as a standalone treatment, making it a reliable option for people who need modest lowering or cannot tolerate statins.123.
When used alongside a statin like rosuvastatin, ezetimibe adds an extra 15–25% reduction in ApoB and LDL cholesterol on top of what statins alone provide without increasing the risk of side effects4567.
Unlike statins, it doesn't affect muscle tissue and isn't processed by the liver's main drug-metabolizing enzymes. Instead, it works in the gut and is metabolized through a milder pathway, making side effects like muscle pain or liver issues very rare.8910.
Ezetimbe, when added to a statin, further lowers the risk of cardiovascular events like heart attack and stroke by about 13–24% and 17–21% respectively911121314.
Not seeing expected results? You can adjust your medication or consult a physician through our Heart Health Program.
Ezetimibe works by blocking cholesterol at the gate: your gut.
Most cholesterol in your bloodstream doesn't come from food directly. It comes from a recycling loop between your gut and liver. The liver secretes cholesterol into the intestine through bile, and a specialized protein called Niemann-Pick C1-Like 1 (NPC1L1) helps reabsorb it back into the body.
Ezetimibe targets that protein. By binding to NPC1L1 in the small intestine, ezetimibe blocks the reabsorption of cholesterol and keeps it from entering your bloodstream. The result: less circulating cholesterol, fewer ApoB-containing particles, and lower LDL cholesterol levels.
This mechanism is completely different from statins, which work in the liver. Ezetimibe works in the intestine and complements liver-based therapies by attacking the problem from another angle.
Ezetimibe is a cholesterol absorption inhibitor used to lower LDL cholesterol and ApoB by blocking dietary and biliary cholesterol uptake in the small intestine. Unlike statins, ezetimibe doesn't interfere with cholesterol production in the liver, making it a well-tolerated option for people seeking gentler alternatives or complements to statins.
To ensure appropriate use, we require recent lab results showing your LDL cholesterol and ApoB levels before starting treatment. If you haven't had these done in the past year, we can help you get them done.
If you're looking for structured medical oversight, we offer the Heart Health Program, which is a physician-led option that includes comprehensive lab testing, 1-on-1 medical support, and a personalized approach to managing both heart and metabolic health.
