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Leqvio Box

Leqvio® (Inclisiran): Twice-Yearly Treatment to Cut ApoB & LDL in Half

Prescription IncludedClinically BackedHSA/FSA Eligible
Leqvio Box

Leqvio® is a next-generation treatment that works at the genetic level. It lowers PCSK9 production to help your body clear LDL cholesterol more efficiently.

$ per injection

Average ~50% Reduction in ApoB & LDL

With just two doses a year after the initial start, Leqvio® delivers powerful and lasting cholesterol lowering.

Mobile Nurse Visit Included

Every injection is administered by a licensed mobile nurse, at your home or office, for convenience and peace of mind.

Direct from Manufacturer

Medication is dispensed directly by the Norvatis, the drug maker, ensuring the highest safety and quality standards.

Why Choose Leqvio®?
A modern, long-lasting option for people who don't want to take daily pills.

Powerful LDL & ApoB Lowering

Leqvio® is a small interfering RNA (siRNA) therapy that “silences” PCSK9 in the liver. With more LDL receptors active, cholesterol is cleared from the blood more effectively. In large clinical trials, LDL dropped by ~50% and ApoB by ~40–50%, even on top of statins or ezetimibe.123

Twice-Yearly Convenience

After the first two doses (month 0 and month 3), you only need one injection every 6 months. This steady dosing avoids the daily burden of pills or frequent antibody injections, helping more patients stay on track long term.45

Cardiovascular Prevention

By cutting LDL and ApoB in half, Leqvio® reduces key drivers of plaque buildup in arteries. Pooled data from large trials suggest a ~24–26% reduction in heart attacks and strokes. Larger outcome studies are ongoing.678

Proven Safety

Leqvio® is generally well tolerated. The most common side effect is mild injection site reactions. Serious events, including liver or kidney issues and new diabetes, occur at similar rates to placebo. Four-year follow-up shows no new safety concerns.39

How to Start Leqvio®
A simple, safe, and data-driven way to begin treatment.

STEP 1
Upload Lab Work
Confirm your eligibility for Leqvio® with recent lab results and a quick health questionnaire.
  • Required: ApoB or LDL cholesterol from the past 12 months.
  • Answer a short health questionnaire to confirm eligibility.
  • Don't have recent labs? Order the Heart Health Test for a complete workup.
Upload Lab Work
STEP 2
Start Treatment
A board-certified lipidologist reviews your labs and health info to ensure Leqvio® is the right for you.
  • Approved by a board-certified lipidologist to ensure safe prescribing.
  • Once approved, your medication is shipped directly to your door.
  • A mobile nurse comes to your preferred location to administer the injection.
Start Treatment
STEP 3
Track Progress
At 2 months, repeat labs to confirm your LDL and ApoB are dropping.
  • Expect to see a ~50% drop in ApoB and LDL cholesterol.
  • Maximum effect usually appears after the second injection.
  • If results aren’t as expected, speak with a board-certified lipidologist through our Heart Health Program.
Track Progress
STEP 4
Ongoing Care
Your second dose is given at 3 months, then every 6 months thereafter.
  • A mobile nurse comes to your preferred location every time.
  • Ongoing physician oversight to ensure safety and effectiveness.
  • Check-ins after each dose to ensure your treatment is working.
Ongoing Care

How Leqvio® Works
The pharmacology behind its powerful, targeted effects.

Leqvio® (inclisiran) switches off the PCSK9 signal inside the liver at the genetic message so LDL can be cleared more efficiently.

Using RNA interference (RNAi), inclisiran pairs with the messenger RNA (mRNA) that encodes PCSK9 and marks it for breakdown. Less mRNA means less PCSK9 protein.

PCSK9 normally flags LDL receptors for destruction. With PCSK9 reduced, more receptors survive, stay active, and keep pulling LDL cholesterol out of the bloodstream.

Bottom line: this removes the brake on your body’s natural LDL-clearing system.

Safety Information

Leqvio (inclisiran) is an injectable cholesterol-lowering medication. It works by blocking production of PCSK9, a protein that normally reduces the liver’s ability to clear LDL cholesterol. With more LDL receptors active, cholesterol levels drop significantly.

Unlike daily pills, Leqvio is given as an injection twice in the first 3 months, then only once every 6 months, which makes it easier to stay on track. It’s typically used for people with heart disease or genetic high cholesterol whose LDL remains elevated despite statins.

If you're looking for structured medical oversight, we offer the Heart Health Program, which is a physician-led option that includes some lab testing, 1-on-1 physician support, and a personalized approach to managing your cardiometabolic health.