Cardio B by Ortho Molecular Products

If you’re looking for a supplement to lower homocysteine, this B‑complex plus betaine is built for that job. It fits adults whose Homocysteine runs high on labs, especially if Vitamin B12 or Folate are low, or if you have an MTHFR gene variant and don’t eat much leafy greens or animal foods. Vegans, long‑term metformin or acid‑reducing drug users (both can lower B12), and oral‑contraceptive users often land here. Recheck Homocysteine after 6–8 weeks to see if one capsule is enough.

Homocysteine is an amino acid byproduct your body needs to recycle. Folic acid and vitamin B12 donate “methyl” tags (small chemical add‑ons) that convert homocysteine back to methionine, while vitamin B6 helps route it toward cysteine. Betaine (trimethylglycine, or TMG) provides a parallel methyl path in the liver that does not rely on folate activation. In practice, this combo drops Homocysteine about 15–30% within 4–8 weeks in most responders. It lowers the marker reliably, though outcome trials show mixed effects on heart events.

Start with one capsule in the morning with food to limit nausea; B12 can feel energizing if taken late. The label allows one or more daily—many clinicians titrate to two if Homocysteine stays high. Check Vitamin B12 or MMA (methylmalonic acid, a functional B12 marker) if you have neurologic symptoms or follow a vegan diet. Re-test Homocysteine in 6–8 weeks and adjust with your clinician.

If you’re on methotrexate for cancer, do not add folic acid without your oncologist. For low‑dose methotrexate used in arthritis, folate is usually co‑prescribed—coordinate dosing. Very high folate can mask blood signs of B12 deficiency, so correct B12 first if your level or MMA suggests deficiency. Pregnancy requires tailored folate dosing; use only under prenatal guidance. If you’ve had unexplained neuropathy, keep vitamin B6 at or below current dosing.