Methyl CpG® by Ortho Molecular Products

If your Homocysteine (a byproduct of protein metabolism linked to heart and brain risk) runs high, or your Folate or Vitamin B12 are low, this methylfolate supplement is on target. It also fits those with MTHFR variants (an enzyme bottleneck that slows folate activation) or on low-folate diets. The dose here is high: about 2 mg of 5‑MTHF plus 1 mg methylcobalamin, useful for repletion, not casual maintenance. Recheck Homocysteine within 4 to 8 weeks.

5‑MTHF (the active folate) and methylcobalamin (active B12) donate methyl groups, which your body uses in methylation, the on/off switch for many reactions. Together they convert homocysteine back to methionine, typically lowering Homocysteine within weeks. Betaine (trimethylglycine) provides a backup methyl pathway in the liver. B6 drives the side-route that disposes of homocysteine, and riboflavin supports the methylation enzymes folate uses, especially helpful for adults whose methylation pathway is less efficient.

Take 1 capsule daily, ideally in the morning with food to reduce nausea and avoid sleep disruption. If you’re sensitive to B vitamins, start 1 capsule every other day for a week, then increase. Pair with labs: Homocysteine, Folate, Vitamin B12, and Methylmalonic Acid (a B12 activity marker) after 8–12 weeks. If your numbers normalize and you feel steady, consider stepping down to a lower maintenance methylfolate/B-complex.

Coordinate with your oncologist if you’re on methotrexate for cancer, as high-dose folate can interfere with therapy. For autoimmune methotrexate, dosing is individualized—don’t self-adjust. Use caution with bipolar spectrum or agitation-prone depression; methylfolate can overstimulate. Pregnancy requires clinician guidance at this dose. If you also supplement B6 elsewhere, total B6 can creep high; persistent tingling or numbness warrants stopping and evaluation.