Liver-G.I. Detox* by Pure Encapsulations

If your liver markers (ALT, AST, GGT on a comprehensive metabolic or hepatic panel) run high-normal or mildly elevated, a liver detox supplement like this is a reasonable trial. It fits people with low seafood intake, regular alcohol use, fatty-liver risk from central weight gain, or multiple medications that tax bile flow. It’s also useful if stool fat is an issue or your hs-CRP (a general inflammation marker) runs up. Expect any lab shifts to show within 4 to 12 weeks.

N‑acetylcysteine and glycine feed glutathione, the liver’s main detox molecule that tags chemicals for removal. Alpha‑lipoic acid helps recycle glutathione and vitamin C. Milk thistle (silymarin) and turmeric (curcuminoids) provide antioxidant and cell-membrane support. Broccoli sprout sulforaphane turns on Phase II enzymes (the liver’s conjugation machinery). Taurine and methionine aid bile acid conjugation, while artichoke supports bile flow. Glutamine helps the gut lining, and chlorella binds some compounds in the intestinal tract so they exit in stool.

Take 2 capsules daily with a meal, ideally one that contains some fat to aid absorption of turmeric and milk thistle. You can split the dose across breakfast and dinner if you’re sensitive. Hydrate well, target daily fiber, and keep protein adequate to supply sulfur amino acids. Recheck ALT, AST, GGT, and hs-CRP after 8 to 12 weeks. If alcohol intake or fasting insulin is high, addressing those usually moves labs more than any supplement.

Skip during pregnancy or breastfeeding, with active gallstones or biliary obstruction, or if you’ve had reactions to turmeric, milk thistle (ragweed family), or chlorella. Turmeric can amplify bleeding risk with warfarin or direct oral anticoagulants. NAC can intensify nitroglycerin, causing headache or low blood pressure. If you’re on chemotherapy or strong immunosuppressants, clear any antioxidant or botanical formula with your oncologist or prescribing team first.