Glutathione-SR 175 mg by Thorne

This fits adults looking to raise glutathione based on real signals: a low-protein or plant-only diet with minimal sulfur amino acids, regularly elevated GGT (gamma‑glutamyl transferase, a liver enzyme that tracks glutathione demand), high hs-CRP (an inflammation marker), or frequent endurance training. It’s also reasonable during periods of higher toxic load like urban air exposure or regular alcohol intake. If you’re after skin “lightening,” oral glutathione gives mixed, modest results; don’t buy it for that goal alone.

Glutathione (reduced form, GSH) is your cells’ master antioxidant that recycles vitamins C and E and fuels glutathione peroxidase (the enzyme that turns peroxides into water). In the liver it powers glutathione S‑transferases, which conjugate toxins (tag them so you can excrete them). Oral GSH historically had spotty absorption, but sustained‑release protects it from stomach breakdown and delivers a steadier blood level, which is what correlates with lower oxidative stress markers in responders.

The suggested use is one capsule two to three times daily, with or without food. Splitting the dose matters here, because the sustained‑release matrix aims for a stable level across the day. Expect any lab‑visible change, like shifts in GGT, hs‑CRP, or ALT (alanine aminotransferase, another liver enzyme), within 4 to 12 weeks. If you need a budget way to raise glutathione longer‑term, N‑acetylcysteine (a glutathione precursor) is a fair alternative.

If you’re on active chemotherapy or immune‑modulating cancer therapy, talk to your oncologist first; antioxidants can interfere with treatment intent. For true deficiency states or very low protein intake, pairing this with cysteine or glycine sources often works better than glutathione alone. Pregnancy and breastfeeding: safety data are limited—use only with clinician guidance. Sulfa drug allergy isn’t a contraindication; that’s a different chemistry class.