Blood type is determined by the presence or absence of specific antigens (proteins) on the surface of red blood cells (RBCs). The most widely used classification is the ABO system, which divides blood into four main types:
Matching donor and recipient blood types is essential to prevent immune reactions. Receiving incompatible blood can trigger the immune system to attack transfused cells, potentially leading to severe complications such as hemolytic reactions, shock, or organ failure.
ABO compatibility is also critical in organ transplantation. Recipients typically need organs from donors with a matching blood type to minimize the risk of immune rejection and improve transplant success rates.