The Rh factor (Rhesus factor) is a protein that may or may not be present on the surface of red blood cells. Its presence or absence determines whether a person’s blood is classified as Rh-positive (Rh+) or Rh-negative (Rh-):
If an Rh-negative mother carries an Rh-positive baby, her immune system may recognize the baby’s red blood cells as foreign and produce antibodies against them. This can result in hemolytic disease of the newborn (HDN), where the baby’s red blood cells are destroyed, leading to severe anemia, jaundice, or, in severe cases, stillbirth.