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Factor VII Activity

Blood Test
See whether one low clotting protein is behind an unexplained long prothrombin time, and how much it raises your bleeding risk before surgery or childbirth.
4.8 (3,863 reviews)
Tested by Quest Diagnostics
Physician-reviewed results
Results in under 1 week
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Should you take a Factor VII Activity test?

This test is most useful if any of these apply to you.

Puzzled by a Long Prothrombin Time
You had a clotting panel and your prothrombin time came back long while the rest looked normal. A low level here is the usual reason.
Bruising or Bleeding More Than Seems Normal
You bruise easily, bleed a long time from small cuts, or have heavy periods, and want to know if a clotting protein is running low.
Carrying a Family Bleeding History
A parent or sibling has a diagnosed clotting protein deficiency, and you want to know whether you carry the same low level.

What Moves This Biomarker

Evidence-backed interventions that affect your Factor VII Activity level

↑ Increase
Recombinant activated factor VII replacement
Raises circulating factor VII and controls or prevents bleeding, including around surgery and delivery. In the STER surgical registry, replacement stopped or prevented bleeding in most procedures, with a past major bleed being the main thing that pushed the dose higher.
MedicationStrong Evidence
↑ Increase
Vitamin K repletion when a deficiency is the cause
Factor VII needs vitamin K to be made in a working form, so when a low level comes from poor vitamin K intake or absorption, restoring vitamin K brings the activity back up. This does nothing for the inherited form, where the gene, not the vitamin, is the problem.
SupplementModerate Evidence

Frequently Asked Questions

References

11 studies
  1. Coagulation Mixing Studies: Utility, Algorithmic Strategies and Limitations
    E. FavaloroAmerican Journal of Hematology2020
  2. Novel Heterozygous F7 Gene Mutation (c.C1286T) Associated With Congenital Factor VII Deficiency: A Case Report and Literature Review
    Hua Tang, X. Luan, Jiaqi Li, Gen Jiang, Haowen Zhen, Hao Li, Wei Xiang, Jie ZhouJournal of Clinical Laboratory Analysis2022
  3. Reproductive Health and Hemostatic Issues in Women and Girls With Congenital Factor VII Deficiency: A Systematic Review
    R. Kadir, K. GomezJournal of Thrombosis and Haemostasis2022
  4. Evaluation of a Prolonged Prothrombin Time
    Joshua L Hood, C. EbyClinical Chemistry2008
  5. Role of Clinical and Laboratory Parameters for Treatment Choice in Patients With Inherited FVII Deficiency Undergoing Surgical Procedures: Evidence From the STER Registry
    M. Di Minno, M. Napolitano, a. Dolce, G. MarianiBritish Journal of Haematology2018