InstalabHerResolve™
Should you take a HerResolve™ test?
This test is most useful if any of these apply to you.
About HerResolve™
If you have painful periods, ongoing pelvic pain, or trouble getting pregnant, you may have spent years being told your tests look normal. Endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus, is one of the most common reasons for exactly this experience, and until recently it took surgery to confirm.
This test offers a molecular answer from a single blood draw. A positive result gives you evidence to act on before you commit to laparoscopy, the keyhole surgery long used to prove the disease is there.
What the Test Measures
The HerResolve test is not one number. It reads a panel of signals in your serum, the clear fluid part of your blood, and combines them with your age and body mass index (a measure of weight relative to height) into a single score using a computer model trained to recognize endometriosis.
The panel includes three tiny genetic fragments that cells release into the blood (called microRNAs), three proteins, and one hormone. The published study does not name each protein individually. The core idea is that pooling seven independent signals, rather than leaning on one, is what lets the score do better than any single marker such as CA-125, the protein most often used as a standalone blood test for this disease.
Why Endometriosis Hides for So Long
Endometriosis is common. It affects an estimated 10 percent of reproductive-age women, roughly 190 million worldwide, and among women who struggle with infertility, as many as 25 to 50 percent have it, though estimates vary and some studies put the lower end nearer 25 percent.
Despite being common, it is slow to catch. The World Health Organization puts the average time from first symptoms to diagnosis at 4 to 12 years, and a study of nearly 7,000 patients found an average delay of 10 years. Part of the problem is the usual blood test, CA-125, which flags only about half of confirmed cases (a sensitivity of 52 percent, meaning it misses roughly one in two).
How Accurate It Is
The test was checked against the strictest standard available: surgery with tissue confirmation. The published study enrolled 298 women with suspected endometriosis across 11 medical centers in the United States, Europe, and Hong Kong. Its headline accuracy numbers, though, come from a smaller validation group of 80 women (40 with the disease and 40 without), and the study was retrospective, a design that tends to make a test look better than it will in everyday use.
| Who Was Studied | What Was Compared | What They Found |
|---|---|---|
| 80 women (40 with and 40 without endometriosis), the validation group | Blood score versus surgery with tissue confirmation | Correctly flagged about 8 in 10 true cases and correctly cleared about 97 or 98 in 100 women who did not have the disease |
| The same women, grouped by menstrual cycle phase | Score accuracy in the first half versus the second half of the cycle | Slightly stronger in the second half of the cycle, but accurate in both |
| Women whose ultrasound or MRI had missed the disease | Blood score versus imaging | Found endometriosis in 61.5 percent of cases that imaging had missed |
Source: Wong et al., Journal of Minimally Invasive Gynecology, 2026.
What this means for you: a positive result is trustworthy, because the test rarely calls someone positive who does not have the disease. A normal ultrasound or MRI does not settle the question, since this blood score picked up most of the cases imaging had already cleared. Keep in mind that a larger prospective study, which follows people forward in time and gives a more reliable read, is still underway.
A Test That Rules In, Not Out
This test is built to confirm endometriosis, not to rule it out. Its strength is that a positive result is seldom wrong, so it gives you solid ground to pursue treatment or a specialist referral.
The trade-off is that it misses about one in five confirmed cases. A negative result does not mean you are in the clear. If your symptoms are real and ongoing, a negative should push you to keep investigating, not to stop.
Where the Guidelines Stand
Mainstream guidance is cautious here. In 2026, the American College of Obstetricians and Gynecologists issued a strong recommendation against using blood or other biomarkers to diagnose endometriosis, concluding that no biomarker tested so far, alone or in combination, has matched the accuracy of surgery.
This test is newer than that review and reports strong numbers, but it has not yet changed guideline practice. Read a positive result as useful evidence that points you toward the right specialists and next steps, not as a final diagnosis on its own.
How to Read Your Result
Because this is a proprietary algorithm run by a single laboratory, there are no universal cutoff numbers you can line up against a different company's test.
| Result | What It Suggests |
|---|---|
| Positive | Strong evidence that endometriosis is present. Reasonable to move toward treatment or a specialist. |
| Negative | Disease was not detected, but this does not rule it out, especially if you still have symptoms. |
These interpretations come from published research on this specific test. Because the assay is new and run by one lab, compare your result only within the same test over time, not against other endometriosis blood tests.
Why One Reading Is a Starting Point
A single result is a snapshot. If you test negative but your pain or fertility problems continue, retesting later or pursuing imaging and a specialist evaluation is the right next move, because the test misses a share of real cases.
This test was validated to detect whether endometriosis is present, not to track how active it is or whether a treatment is working. Do not read a later change in your result as proof that a therapy succeeded or failed, since that use has not been studied. If you are symptomatic and have never been tested, getting a baseline now is the most useful step while the science, including the prospective study still in progress, continues to mature.
When a Result Can Mislead You
- Where you are in your cycle: the model already adjusts for menstrual phase, but accuracy was slightly lower in the first half of the cycle than the second, so ask whether your lab has a preferred timing.
- It is meant for people with symptoms: the test was validated in women with suspected endometriosis, not as a general screen for women without symptoms, so a result in someone with no symptoms has not been studied.
- A negative when your symptoms are real: because it misses about one in five true cases, a negative can be falsely reassuring, and ongoing symptoms still deserve a workup.