Does Weekly Rapamycin Make Exercise Work Better in Older Adults?
In 40 sedentary adults aged 65 to 85, adding 6 mg of weekly sirolimus, the prescription drug also known as rapamycin, to a 13-week home exercise program did not improve function over exercise alone. Both groups got better, but the drug group gained about two fewer chair-stands than placebo in the main analysis, and the per-protocol sensitivity analysis, limited to adherent participants, favored placebo more strongly. This one small trial does not settle rapamycin's broader longevity question, but it does not support taking it to get more out of workouts.