OsteoPrev® by Ortho Molecular Products

If your DEXA scan shows declining bone density or your Vitamin D, 25-Hydroxy is low, this bone density supplement is a practical next step. It fits post‑menopausal women, smaller-framed adults, people on low-calcium diets, and anyone limiting dairy. It also suits long-term proton pump inhibitor users and those on aromatase inhibitors, where bone loss risk is higher. If you already take high-dose calcium, this formula layers in vitamin K2 and ipriflavone without overloading calcium.

Ipriflavone (600 mg/day) slows osteoclasts, the cells that break down bone, and in trials preserved bone density when paired with calcium. Vitamin K2 as MK‑7 activates osteocalcin (the protein that locks calcium into bone) and matrix Gla protein (the protein that helps keep calcium out of arteries). Vitamin D3 1,000 IU improves calcium absorption and tamps down parathyroid hormone, the signal that pulls calcium from bone. Boron, magnesium, and trace minerals round out bone remodeling support.

Take four capsules daily in two divided doses with meals, which improves calcium and magnesium uptake. The calcium here (250 mg/day) is a modest maintenance amount; if your dietary calcium is low, add food sources or a separate calcium to reach your target. Expect changes in bone turnover markers like CTX and P1NP within 8–12 weeks, with DEXA changes judged over 6–12 months. Recheck Vitamin D, 25-Hydroxy after 8–12 weeks and adjust D3 if still low.

Skip this if you take warfarin (Coumadin); the high vitamin K1 and K2 will interfere with dosing. Separate by at least four hours from thyroid hormone, tetracycline or quinolone antibiotics. Avoid in pregnancy and breastfeeding, as ipriflavone data are limited. If you have high blood calcium, recurrent calcium kidney stones, or conditions that raise calcium like sarcoidosis, use only with clinician guidance and monitor serum calcium and PTH.