Glycine 1500 mg by Pure Encapsulations

If you sleep hot, wake unrefreshed, or get restless in the second half of the night, glycine is a practical first test. A bedtime dose has been shown to improve subjective sleep quality and next‑day alertness within days. It also fits people managing stress or tracking fasting glucose or HbA1c (long-term blood sugar) who want a non-sedating aid. If your homocysteine (a methylation byproduct tied to B-vitamin status) runs high, glycine pairs well with folate and B12.

Glycine acts as an inhibitory neurotransmitter (a calming signal) and a co-agonist at NMDA receptors (a brain receptor involved in learning and sleep regulation), which smooths nighttime arousal. It also nudges core body temperature down slightly, helping you fall asleep faster. Beyond sleep, glycine is a building block for glutathione (the cell’s main antioxidant), creatine (an energy buffer for muscle and brain), and collagen, and it supports liver conjugation (tagging compounds for safe clearance).

For sleep, 3 grams about 30–60 minutes before bed is the studied dose; most people feel a difference within 1–7 nights. For daytime calm, split smaller amounts between meals as the label suggests, then move most of the total to bedtime if sleep is your goal. If you’re also targeting metabolic markers like fasting glucose, expect any change over 8–12 weeks. Start lower if you’re sensitive, then titrate.

Glycine is well tolerated, with occasional nausea or loose stools at higher doses. Use caution if you have chronic kidney disease or are on dialysis; discuss protein and amino acid loads with your clinician. If you take clozapine or use ketamine, talk with your prescriber because glycine influences the same NMDA pathway. Pregnancy and breastfeeding: safety data are limited, so avoid unless your clinician recommends it.