Cellular Longevity PRO, Mitopure (Urolithin A) 1000mg by Timeline

Urolithin A is for adults in midlife and beyond who already train and eat enough protein, and who want to support muscle and mitochondrial function as they age. It is an addition to exercise, which does far more for mitochondria than any capsule. Gut bacteria make urolithin A from compounds in pomegranates, walnuts and berries, but many people produce little or none of it from food, which is the reason to take it directly. No routine blood test shows whether you make it or whether a supplement is working.

Mitopure is a branded form of urolithin A. In cell and animal studies, urolithin A triggers mitophagy, the process by which cells break down worn-out mitochondria so newer ones can take their place. Mitochondria turn food into usable energy, and their upkeep slows with age, most noticeably in muscle. In small randomized trials in middle-aged and older adults, most of them funded by the maker, daily urolithin A was followed by modest gains in some measures of muscle strength and endurance. Other measures, such as walking distance, did not clearly change.

A serving is 2 capsules, which provide 1000 mg of urolithin A, and the bottle holds 30 servings. The label's suggested use is 2 capsules daily, with meals or on an empty stomach, and it advises taking it for a minimum of 4 months for best results. Pick a time of day you will keep to.

Urolithin A was well tolerated in trials lasting up to 4 months, with side effects much like placebo. Longer-term safety data are limited. No drug interactions have been established, which is not the same as proof that there are none. The label says it is for adults only, and to consult a healthcare practitioner first if you are planning a pregnancy, pregnant, nursing, expecting surgery, taking medication regularly or under medical supervision.

Do not expect to feel it day to day. In trials, changes in muscle measures took about 2 to 4 months to show, which fits the label's advice to take it for at least 4 months. Judge it then, alongside regular training. The evidence so far is early: encouraging for muscle function, unproven for lifespan or for any disease. Pomegranate juice or extract is not an equivalent, because how much urolithin A you make from it depends on your gut bacteria.