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Lithium is a naturally occurring element found in small amounts in drinking water and food. Here it is bound to orotic acid, and each capsule supplies 20 mg of lithium. That is more than many lithium supplements provide and still well below prescription lithium, which is dosed many times higher and managed with regular blood tests. How small amounts of lithium act in the body is not settled, and the idea that the orotate form is absorbed better or reaches the brain more easily has not been shown in people.
The label directs 1 capsule daily with a meal and says not to exceed that dose; the bottle holds 90, and it is labeled for adults only. Drink plenty of fluid with it. Lithium leaves the body through the kidneys and follows sodium, so dehydration, heavy sweating, vomiting, diarrhea or a sudden low-salt diet can raise the level in your blood. For use beyond a few weeks, ask your clinician about checking TSH, Creatinine and a Lithium level.
Do not use it if you are pregnant, trying to conceive or nursing, or if you have kidney disease or a thyroid condition, unless your clinician has agreed. Several common medicines slow the kidneys' clearance of lithium and can push levels up: diuretics (water pills), NSAIDs such as ibuprofen and naproxen, and ACE inhibitors and related blood pressure medicines. Never combine it with prescription lithium, and ask your prescriber before taking it with antidepressants, antipsychotics or other psychiatric medicines. Stop and seek care for tremor, nausea, diarrhea, unusual thirst, frequent urination, drowsiness or confusion.
Keep expectations modest. Evidence for lithium supplements in healthy adults is limited, drawn mostly from population studies of lithium in drinking water and a few small trials, so there is no reliable timeline for an effect. If you and your clinician see no benefit after 2 to 3 months, stop. Lower-strength lithium orotate products are a more cautious starting point for most people; this strength makes the most sense when a clinician has chosen it.
No. Prescription lithium is a medicine given at much higher doses with regular blood tests. Lithium orotate is a mineral supplement. It is not a substitute for prescription lithium, and the two should never be taken together or swapped without your prescriber.
The label lists 20 mg of lithium, from lithium orotate, per capsule. That is on the high side for a lithium supplement. The label says to take 1 capsule daily with a meal and not to exceed that dose. Tell your clinician you are taking it.
People who are pregnant, trying to conceive or nursing, and anyone with kidney disease or a thyroid condition, unless a clinician has agreed. The same goes for anyone on prescription lithium, other psychiatric medicines, diuretics, NSAIDs or ACE inhibitors. The label says it is for adults only.
Yes. Diuretics, NSAIDs such as ibuprofen and naproxen, and ACE inhibitors and related blood pressure medicines reduce how fast the kidneys clear lithium, which can raise blood levels. Check with your clinician or pharmacist before combining them.
Only if your prescriber agrees. Lithium can interact with antidepressants, antipsychotics and other psychiatric medicines. Do not add it to your treatment plan, or use it in place of a prescribed medicine, without talking to the clinician who manages it.
At this strength it is sensible. Ask your clinician about a baseline and periodic TSH and Creatinine, since lithium can affect the thyroid and is cleared by the kidneys. A Lithium level can also be measured if there is any concern about how much is building up.
Hand tremor, nausea, diarrhea, unusual thirst, frequent urination, drowsiness, unsteadiness or confusion. Stop taking it and get medical care if these appear, especially during dehydration, a stomach illness or after starting a new medicine.
There is no reliable timeline. Research on lithium supplements in healthy adults is limited, and many people notice nothing. If you and your clinician see no benefit after 2 to 3 months, it is reasonable to stop.