GI Effects Inflammation-Associated Dysbiosis Test

The Inflammation-Associated Dysbiosis is a computed index that looks at the overall pattern of your usual gut bacteria (commensals) and asks: does this pattern look like what we see in people with inflamed intestines, such as inflammatory bowel disease (IBD)? It’s built from a pattern-based algorithm that was developed on a very large stool-testing dataset and validated in IBD cohorts. Higher IAD scores are linked to lower total commensal abundance and higher levels of stool inflammation markers like calprotectin, eosinophil protein X (EPX), and secretory IgA (sIgA).

A low IAD score with high inflammatory markers suggests the gut microbiome pattern itself is less likely to be the main driver of inflammation, so other causes (like infection, food reactions, or structural disease) should be investigated. In contrast, a high IAD score with normal inflammatory markers is less well understood; it may mean your microbiome has shifted toward a more inflammatory pattern that could precede a rise in the standard stool inflammation markers, which is why clinicians interpret the IAD score alongside symptoms and other lab findings rather than in isolation.