Cardio MET Pack by Ortho Molecular Products

If your Triglycerides run high and your A1c or fasting glucose is creeping up, this combination of omega-3, berberine, bergamot, and alpha-lipoic acid is built for you. Omega-3 for high triglycerides is the anchor here: most responders see a 20–30% drop within 4 to 12 weeks. Berberine modestly lowers fasting glucose and A1c, useful if your A1c is in the higher end of normal. Bergamot targets LDL and non-HDL cholesterol, which tracks with ApoB (the number of atherogenic particles). It’s a practical fit if your Omega-3 Index is low and your hs-CRP (a general inflammation marker) runs elevated.

EPA and DHA (the long-chain omega-3 fats) reduce how much fat your liver exports in VLDL particles (the triglyceride carriers) and can nudge down hs-CRP. Berberine activates AMPK (the cell’s fuel gauge that improves how you use glucose and fat), which helps insulin sensitivity and may reduce PCSK9 (a liver protein that raises LDL). Bergamot polyphenols act at the liver’s cholesterol-making step (the same pathway statins target), improving LDL and non-HDL. Alpha-lipoic acid regenerates antioxidants like glutathione and improves insulin sensitivity, especially when glucose is high.

Take one daily packet with a meal that contains some fat; omega-3 absorbs better with food and you’ll reduce fishy burps. The 1,900 mg total omega-3 as triglycerides is a clinically useful dose for triglycerides. Berberine at 500 mg once daily is an entry dose; many protocols use 500 mg two to three times daily with meals for glucose control, so your clinician may add a separate berberine capsule if labs warrant. Expect triglyceride changes in 4–12 weeks and A1c changes over 8–12 weeks.

If you use insulin or sulfonylureas, berberine and alpha-lipoic acid can lower glucose further; monitor and coordinate dose changes. Berberine interacts with cyclosporine, tacrolimus, and many drugs moved by CYP3A4/P-glycoprotein. Bergamot plus a statin is additive for LDL; report new muscle pain. High-dose omega-3 has a small bleeding signal; use caution with warfarin and other blood thinners. Pregnancy and breastfeeding: avoid berberine. Significant liver or kidney disease: use only with clinician oversight.