N-Acetyl Cysteine 500 mg by Ortho Molecular Products

If you’re trying to raise glutathione (the body’s master antioxidant) without IVs, a NAC supplement is the practical route. It fits adults with frequent sinus congestion or thick mucus, and those watching liver enzymes like ALT and AST after alcohol, medications, or fatty liver patterns. People with elevated oxidative stress markers such as GGT (a liver-related enzyme linked to oxidative load) or hs-CRP (a general inflammation marker) sometimes see modest improvements. Vegans and vegetarians, who may run lower in sulfur amino acids, are common responders.

N-acetyl cysteine is a stable form of cysteine, the rate-limiting building block your cells use to make glutathione. By supplying cysteine, it replenishes glutathione in the liver and lungs, where it helps neutralize reactive oxygen species (damaging byproducts of metabolism) and supports detoxification enzymes. In the airways, NAC breaks disulfide bonds in mucus, making it less sticky and easier to clear. Clinical trials show symptom relief in chronic bronchitis and COPD, and small studies suggest modest drops in hs-CRP in some users.

This capsule delivers 500 mg. Start with one daily, preferably with food to limit nausea. For mucus-heavy seasons, many adults use 500–600 mg twice daily for a few weeks, then step down. Expect clearer mucus within 1–2 weeks and glutathione-related effects over 2–4 weeks. If you’re targeting liver health, recheck ALT, AST, and GGT after 8–12 weeks. Pairing with vitamin C helps recycle glutathione, but if you also take selenium or milk thistle, introduce changes one at a time and track labs.

NAC amplifies the effects of nitroglycerin (used for chest pain), which can trigger low blood pressure and headache—avoid this combo unless your cardiologist approves. If you’re on blood thinners or antiplatelet drugs, be cautious; NAC has mild antiplatelet activity. Coordinate timing with chemotherapy or radiation, as antioxidants can interfere with some protocols. Asthma is generally fine with oral NAC, but stop if wheezing increases. Common side effects are nausea or reflux; take with food or reduce the dose. Pregnancy and nursing: discuss with your clinician.