SBI Protect® Powder 2.5 g by Ortho Molecular Products

If you’re chasing “leaky gut” fixes, bovine immunoglobulin is one of the few with real-world data. It’s a fit for adults with frequent loose stools, food-triggered gut discomfort, or athletes with exercise-related GI upset. It’s also useful after travel or antibiotics when your gut barrier feels off. If your hs-CRP (a blood marker of inflammation) runs high and gut symptoms are active, this is worth a trial. Vegans should skip it, as it’s bovine-derived.

Serum‑derived bovine immunoglobulin is concentrated IgG antibodies (proteins that bind targets) purified from bovine serum. In the gut, these IgG bind bacterial fragments like LPS (endotoxin from gram‑negative bacteria), flagellin (a bacterial protein), and dietary antigens. Binding keeps these triggers in the lumen, helps carry them out in stool, and reduces immune activation at the lining. People often see firmer stools within 1–2 weeks, with steadier gains by 4 weeks. Compared with colostrum, this form is standardized for IgG and essentially lactose-free.

Mix one scoop in cool water or a non‑acidic beverage twice daily, as directed. Start with once daily for 3–4 days, then increase if you tolerate it. Room‑temperature liquids preserve protein structure; avoid hot coffee or tea. Timing with meals isn’t critical. If you use gut‑active add‑ons (glutamine, zinc carnosine, probiotics), you can take them the same day. Most responders notice changes in stool form within 1–2 weeks.

Because bovine immunoglobulin binds a range of molecules in the gut, take it at least 2 hours away from oral medications and fat‑soluble supplements you need fully absorbed. It pairs well with probiotics and fiber. If you use bile acid binders (like cholestyramine) or orlistat (a fat‑absorption blocker), separate by several hours to avoid unpredictable binding.

Skip this if you have a known beef or bovine‑protein allergy. Most people with lactose intolerance tolerate it, but those with severe milk‑protein allergy should use caution and consult a clinician. Pregnancy and breastfeeding: safety data are limited; use only with clinician guidance. Strict vegetarians and vegans will want a non‑animal alternative.