Magnesium Glycinate 120 mg by Pure Encapsulations

If you’re low on magnesium by diet or labs, magnesium glycinate is a gentle way to replete without the laxative effect common with oxide or citrate. It fits athletes with muscle cramps, high-stress professionals with tense muscles and poor sleep, and people on proton pump inhibitors or diuretics, which can deplete magnesium. If your Serum Magnesium is normal but symptoms persist, checking Magnesium, RBC (magnesium inside red blood cells) can clarify tissue status.

Glycinate is magnesium bound to glycine, an amino acid that’s calming for the nervous system. This chelate is well absorbed and easy on the gut, so you get more elemental magnesium into cells, where it stabilizes nerve signaling and muscle relaxation. In practice, people notice fewer nighttime leg cramps and smoother sleep onset. Compared with citrate or oxide, you’ll see less stool loosening at similar elemental doses, which makes staying consistent much easier.

Each capsule provides 120 mg elemental magnesium; the suggested 1–4 capsules daily gives 120–480 mg. Take with food, and split doses morning and evening if you’re aiming above 240 mg. For sleep or muscle tension, place the larger portion in the evening. This is a practical maintenance-to-repletion range; if you have established deficiency, you may need the higher end for 4–8 weeks, then step down once symptoms and labs improve.

Separate magnesium by at least 2 hours from antibiotics like tetracyclines or fluoroquinolones, and by 4 hours from levothyroxine or oral bisphosphonates, since it binds these drugs and blocks absorption. It can add to the blood-pressure–lowering effect of antihypertensives, so monitor if you’re sensitive to drops. Alcohol increases urinary magnesium loss, which can raise your needs, but taking them together isn’t harmful.

Significant kidney disease reduces magnesium clearance—avoid unless your clinician is monitoring levels. If you develop persistent diarrhea, cut the dose or switch timing; loose stools mean you’re exceeding what your gut can absorb. Pregnancy and breastfeeding are generally compatible with dietary magnesium, but supplement dosing should be reviewed with your obstetric clinician.