Magnesium Glycinate Liquid 165 mg by Pure Encapsulations

If you get muscle tightness at night, sleep is inconsistent, or other magnesium forms upset your stomach, magnesium glycinate fits. It’s well suited for people whose Magnesium, Serum or Magnesium, RBC (magnesium inside red blood cells) runs low or low‑normal, for athletes with heavy sweat loss, and for those on proton pump inhibitors or diuretics that can lower magnesium. The 165 mg per serving is a maintenance-level dose for steady repletion without laxative effects.

Glycinate is magnesium bound to glycine, an amino acid that helps absorption and makes it gentler on the gut than citrate or oxide. Magnesium regulates calcium flow in muscle cells, which is why adequate levels ease nocturnal cramping and jaw or calf tightness. It’s a cofactor for ATP production (your cells’ energy currency) and helps calm brain signaling by modulating NMDA receptors (the switches that control excitability). Glycine itself has a mild calming effect for some people.

Take 2 teaspoons daily with a meal as directed. If sleep is your goal, evening is reasonable; if muscle tension dominates your day, split half with breakfast and half with dinner. Liquid is easy to titrate: increase slowly if your Magnesium, RBC is low, or hold steady for maintenance. If you truly need higher daily amounts, a capsule or powder with more elemental magnesium per serving is more practical.

Separate magnesium from levothyroxine, doxycycline or other tetracyclines, fluoroquinolone antibiotics, and bisphosphonates by at least 2–4 hours to avoid reducing drug absorption. People with significant kidney disease should only supplement under clinician supervision. Glycinate rarely causes loose stools, but back down if it does. If you’re on diuretics or long-term acid-reducing medicines, consider checking Magnesium, Serum or Magnesium, RBC and adjust with your clinician.