Magnesium Glycinate 120 mg by Thorne

If you’re dealing with muscle tightness at night, restless sleep, or stress that shows up as jaw clenching or twitchy calves, magnesium glycinate is a good fit. It’s also useful if your Serum Magnesium runs low-normal, or your Magnesium, RBC (magnesium inside red blood cells) is low, which often tracks with symptoms. Vegans, heavy exercisers with sweat loss, people on proton pump inhibitors, and those with high caffeine intake are common candidates.

Glycinate is magnesium bound to glycine, an amino acid with a calming effect at NMDA receptors (a nerve signal gateway tied to excitability). This chelated form absorbs well and is gentler on the gut than oxide or high-dose citrate, so you get magnesium into cells without a laxative tradeoff. Adequate magnesium steadies nerve firing, relaxes muscle after contraction, and helps enzymes that regulate energy and glucose handling, which is why cramps and sleep often improve.

Thorne’s capsule provides 120 mg per dose. Take one capsule with an evening meal for sleep or muscle goals; if needed, add a second capsule 1–2 hours before bed. Daytime stress or tension often responds to dividing doses morning and evening. Repletion usually takes 4–8 weeks, then you can step down to the lowest dose that keeps symptoms quiet. If your levels are very low, you’ll likely need a higher total daily amount under clinician guidance.

Separate magnesium from tetracycline or quinolone antibiotics, levothyroxine, and bisphosphonates by at least 4 hours, since minerals reduce their absorption. Diuretics can raise or lower magnesium needs, so check labs if you use them. Advanced kidney disease is a reason to avoid unsupervised magnesium due to buildup risk. For blood pressure drugs, magnesium can have a small additive lowering effect—monitor if you’re sensitive to drops.