MediClear Plus by Thorne

If you’re running an elimination diet or want a low-allergen shake that actually feeds liver clearance pathways, this detox protein powder fits. It’s useful when liver enzymes (ALT, AST, GGT on a metabolic panel) run high, if your homocysteine (a methylation byproduct) is elevated, or if your Omega-3 Index and choline intake are low. The pea-and-rice base suits dairy- and soy-avoiders, and the balanced B vitamins make it practical as a once-daily anchor during a 2–8 week reset.

Your liver transforms compounds in two steps. Step one makes them more reactive; step two tags them for exit. This formula supplies the taggers: glycine, glutamine, and taurine feed conjugation (the attachment step); methylfolate and methylcobalamin provide methyl groups for methylation (a chemical tag); and glutathione supports antioxidant defense. Milk thistle (silymarin) and green tea polyphenols protect liver cells, while curcumin phytosome is better absorbed than plain curcumin and can lower inflammation markers like hs-CRP in responders. Choline and betaine help export liver fat as VLDL particles (the form your liver uses to ship triglycerides).

Mix two scoops in water or a smoothie once daily with food. If you’re new to higher-protein shakes, start at one scoop for 3–4 days, then increase to the full dose to limit bloating. Separate from medications like levothyroxine and certain antibiotics by at least two hours, since minerals and protein can affect absorption. Using it as a meal? Add fiber (chia or psyllium) and a little fat if you want longer satiety.

Curcumin, green tea extract, and milk thistle can interact with blood thinners (warfarin, apixaban, clopidogrel) and some chemotherapy—check with your clinician. Avoid if you have gallbladder obstruction, active bile duct stones, or significant liver disease unless supervised. High-protein powders aren’t ideal if you’re on a protein-restricted plan for kidney disease. Pregnancy and breastfeeding: choose a prenatal and discuss single-ingredient choline instead.