Osteo-K Minis by NBI

If a DXA scan shows low bone density, or you’re post‑menopausal or on long-term steroids, vitamin K2 MK-4 with calcium citrate and vitamin D3 is a targeted stack. It’s useful when your Vitamin D, 25-Hydroxy is in the lower end of normal and you want a maintenance dose, not a repletion plan. Dairy-light eaters and adults with high bone turnover markers (P1NP and CTX, the lab signals of bone remodeling) are common fits.

MK-4 (a form of vitamin K2) activates osteocalcin and matrix Gla protein, the proteins that guide calcium into bone and keep it out of arteries. Clinical trials in Japan used multi‑milligram MK-4 to maintain bone density and reduce vertebral fractures. Vitamin D3 raises calcium absorption and keeps parathyroid hormone (the signal that pulls calcium from bone) in check. Calcium citrate supplies absorbable calcium and is gentler for people with sensitive stomachs.

Take 2 capsules twice daily with meals as directed; fat in a meal improves absorption of vitamin K2 MK-4 and vitamin D3, and splitting calcium improves uptake. The 25 mcg D3 is a maintenance dose; if your Vitamin D, 25-Hydroxy is low, repletion usually needs higher doses short term. The 200 mg calcium citrate here is supplemental, so count your diet to reach an appropriate daily total.

Do not use vitamin K2 MK-4 with warfarin or other vitamin K–antagonist blood thinners; it opposes their effect. Separate calcium from levothyroxine by 4 hours, and from tetracyclines or fluoroquinolones by at least 2–6 hours to avoid blocking absorption. Take calcium away from morning bisphosphonates. If you have high calcium, primary hyperparathyroidism, sarcoidosis, or significant kidney disease, talk with your clinician first.