Orthomega® Select EPA by Ortho Molecular Products

This is a fit if you want a high EPA fish oil for mood and inflammation with minimal DHA. One softgel delivers 660 mg EPA and 60 mg DHA, a ratio often used alongside therapy for low mood and for joint comfort. It’s also practical if your Omega-3 Index is low and you want an EPA-leaning bump without a large DHA load, which some people prefer if their LDL-cholesterol tends to rise on standard fish oil. If your triglycerides are elevated, meaningful reductions usually need higher total omega-3 intake than one softgel.

EPA and DHA are long-chain omega-3s. EPA shifts cell-membrane signaling toward fewer inflammatory eicosanoids (hormone-like messengers), which is why some see small drops in hs-CRP (a blood marker of inflammation). In the liver, these fats reduce how much fat is packaged into VLDL particles (the form that appears on a lipid panel as triglycerides). High EPA, low DHA blends are also the formulation most studied as an add-on for depressive symptoms. This product is in the natural triglyceride form, which is well absorbed when taken with a meal containing fat.

Take one softgel daily with a meal that contains fat, as the manufacturer suggests. For mood or general maintenance when the Omega-3 Index is low-normal, one daily is reasonable for 8 to 12 weeks before rechecking labs. For triglyceride lowering, most responders need grams, not milligrams, of EPA+DHA per day, so discuss 2 to 4 softgels or a higher-strength option with your clinician. Splitting doses with meals and storing capsules in the freezer can reduce fishy burps.

Use caution if you take warfarin, high-dose aspirin, or antiplatelet drugs like clopidogrel; bleeding risk is low at typical doses but coordinate dosing and any pre-op holds with your team. Skip if you have a fish allergy. Planning pregnancy or pregnant? A DHA-rich omega-3 is usually preferred for fetal brain needs. If you have bipolar disorder, only use omega-3s for mood under your psychiatrist’s guidance.