PhytoPre by Ortho Molecular Products

Bloating that flares with fiber is the classic SIBO scenario. A non-fiber, polyphenol prebiotic fits people who react to inulin or FOS but still want to feed the gut lining and shape the microbiome. It’s a good trial if your Hydrogen–Methane Breath Test suggests SIBO, you’re on a low-FODMAP plan, or you’re rebuilding after antibiotics. If Fecal Calprotectin (a stool inflammation marker) or hs-CRP (blood inflammation marker) are elevated, polyphenols are a reasonable add-on while you address root causes.

Pomegranate extract (rich in punicalagins) and citrus bioflavonoids reach the colon largely intact, where microbes convert them into small phenols like urolithins that favor beneficial species and increase production of butyrate, the fuel your colon cells run on. Unlike fiber, these compounds don’t ferment into gas, so they’re gentler for SIBO. Citrus bioflavonoids also blunt bacterial quorum sensing (their “group chat” for overgrowth) and support gut-barrier integrity, which reduces passage of LPS (bacterial fragments) into the bloodstream and can modestly lower inflammation in responders.

Take 2 capsules daily with food; many prefer breakfast. If you’re sensitive, start with 1 capsule for a week, then increase. Most notice less bloating or more predictable stools within 1–3 weeks, with microbiome and inflammation changes building over 4–8 weeks. You can pair this with a probiotic or digestive protocol; separate from other supplements only if your stomach is touchy.

Avoid if you have a citrus allergy. Citrus and pomegranate polyphenols can interact with drug metabolism. If you take warfarin or other blood thinners, or statins like simvastatin or atorvastatin, check with your clinician first. During pregnancy or breastfeeding, use only with professional guidance. If symptoms worsen after a week, stop and reassess for active infection, constipation, or inadequate SIBO management.