Saccharomyces Boulardii 5 billion CFU by Ortho Molecular Products

If you’re starting antibiotics or heading to places with uncertain food and water, Saccharomyces boulardii probiotic is one of the few with consistent data for loose stools. It’s useful if you’ve had antibiotic‑associated diarrhea before or a history of C. difficile (a toxin‑producing bacterium that can recur). People with low fecal sIgA (secretory IgA, the first‑line antibody in the gut) on stool testing, and those who don’t tolerate bacterial probiotics, also tend to do well with this yeast.

This probiotic is a non‑colonizing yeast that passes through, shaping the gut environment while you take it. It increases secretory IgA (the antibody that coats the gut lining), helps block pathogen adhesion, and can bind and neutralize bacterial toxins, including those from C. difficile. It also supports digestive enzymes at the brush border (the gut’s absorptive surface) and helps tighten leaky junctions, which explains why stool frequency and consistency often improve within days.

The suggested use is 1 capsule twice daily, providing 10 billion CFU per day. Take with or without food. If you’re on antibiotics, start the same day and separate doses by at least 2–3 hours. For travel, begin 3–5 days before departure and continue through the trip. Most people notice steadier stools within 3–7 days; give it up to 2 weeks in tougher cases.

Antifungal drugs like fluconazole or nystatin will inactivate this probiotic; use a different strategy if you need those medicines. Rare bloodstream infections have been reported in critically ill or profoundly immunocompromised patients and in those with central venous catheters, so avoid in those settings. If you have recurrent invasive fungal infections, discuss with your clinician first.