NAC 500 mg by Thorne

If you’re run down from frequent winter infections or dealing with stubborn mucus, NAC supplement use is practical. It’s also useful if your oxidative stress looks high on labs, like an elevated GGT (a liver enzyme that reflects glutathione turnover) or hs-CRP (a general inflammation marker). People with heavy acetaminophen use, urban pollution exposure, or intense training blocks often benefit. If your ALT or AST (liver enzymes) run high, NAC is sometimes part of a broader liver plan while you address root causes.

N-acetylcysteine is a cysteine donor that your cells use to make glutathione, the main intracellular antioxidant that protects proteins, fats, and DNA from oxidation. More glutathione improves detox chemistry in the liver by binding certain toxins for removal. In the airways, NAC breaks disulfide bonds in mucus, making it less sticky and easier to clear. These actions explain why some people see modest drops in hs-CRP and steadier liver enzymes over weeks, and easier breathing within days during congested periods.

The suggested use is 1 capsule two to three times daily. Most adults do well between 600 and 1,800 mg per day, divided. Take with food if you’re prone to nausea; empty-stomach dosing absorbs well but can feel queasy. If your goal is mucus relief, twice-daily timing during the day is common. For glutathione repletion, steady daily use for 4 to 12 weeks is typical before rechecking hs-CRP, GGT, or liver enzymes. Pairing with vitamin C is reasonable but not required.

NAC potentiates nitroglycerin and isosorbide (used for chest pain), often causing significant headache and lightheadedness—don’t combine unless your cardiologist approves. It has mild antiplatelet effects, so use caution with warfarin, DOAC blood thinners, or high-dose fish oil. Activated charcoal can reduce absorption if taken together. Asthma is not a strict contraindication with oral NAC, but monitor for cough or bronchospasm. Pregnancy and breastfeeding: data are limited; use only with clinician guidance.