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Alpha-lipoic acid is a small molecule made in the body and found in foods like spinach, broccoli, and organ meats. It is both water- and fat-soluble, which lets it work as an antioxidant inside cell membranes and in the watery interior of cells. Inside mitochondria, the cell's energy-producing compartments, alpha-lipoic acid serves as a cofactor for enzymes that convert nutrients into ATP, the chemical form of energy your cells use. Biotin is a B vitamin (vitamin B7) that the body also uses as a cofactor in energy metabolism and in the building of fatty acids and amino acids.
Take one tablet 30 minutes before breakfast and one tablet 30 minutes before dinner, or as directed by your healthcare professional. Alpha-lipoic acid is absorbed better on an empty stomach, so a window of about 30 minutes ahead of a meal works well. A 120-tablet bottle is roughly a 60-day supply at two tablets per day.
If you take prescription medications, are pregnant or breastfeeding, or are working with a clinician on any health condition, talk to your care team before starting and review the warnings below.
Alpha-lipoic acid is a small molecule made in the body and also found in foods like spinach, broccoli, and organ meats. It acts as an antioxidant and as a cofactor for enzymes inside mitochondria that help convert nutrients into ATP, the chemical form of energy cells use.
The controlled-release matrix lets the alpha-lipoic acid dissolve gradually across the dosing interval. That tends to even out blood levels and is often easier on the stomach than a fast-release format, where the full dose is released within minutes.
Take one tablet 30 minutes before breakfast and one tablet 30 minutes before dinner, or as directed by your healthcare professional. Alpha-lipoic acid is absorbed better on an empty stomach.
At two tablets per day, the 120-tablet bottle is roughly a 60-day supply.
Taking it 30 minutes before a meal is the usual recommendation, since absorption is better on an empty stomach. If you find it hard on your stomach, talk with your clinician about timing options that work for you.
Biotin can interfere with some hormone and cardiac assays at higher intakes. The 450 mcg here is a modest amount, but tell your lab and clinician you take biotin, and consider pausing it 24 to 48 hours before sensitive blood tests if your clinician advises.
Separate alpha-lipoic acid from thyroid hormone replacement by at least 4 hours to reduce the chance of reduced absorption. Talk with your clinician about the timing that fits your routine.