Cortisol Manager by Integrative Therapeutics

If you want a calm wind-down without melatonin, this is the original tablet form of Cortisol Manager. It suits adults navigating high-stress stretches, those whose evenings feel mentally busy, and anyone who tolerates the soy-derived phosphatidylserine source used in this formula. Per Integrative Therapeutics, the formula supports a balanced cortisol response and helps stabilize the stress hormone cortisol to further support a healthy stress response.

Sensoril® ashwagandha is a standardized extract; in a 2008 placebo-controlled trial cited by the manufacturer, it significantly reduced serum cortisol compared to placebo. L-theanine supports a relaxed-alert state through alpha brain-wave activity. Magnolia bark extract, standardized to 2% honokiol (6 mg) and 1% magnolol (3 mg), and epimedium aerial-parts extract together compose the cortisol-reducing proprietary blend. Phosphatidylserine, a phospholipid sourced here from soybean lecithin, contributes to the membrane signaling involved in the body's stress-feedback system.

Per Integrative Therapeutics: adults take 1 tablet before bedtime, or as recommended by a healthcare professional. Increase to 2 tablets during periods of high stress. For nightly use. Many people notice calmer pre-sleep within the first nights; broader stress-pattern benefits typically develop over 2 to 8 weeks of consistent use.

If you take prescription medications, are pregnant or breastfeeding, or are receiving cancer treatment, talk to your clinician before starting and review the warnings below.