Pro-Resolving Mediators 500 mg by Thorne

If your training, joints, or recovery feel stuck on “simmer,” a specialized pro-resolving mediators (SPM) supplement based on omega-3 can help you complete the aftermath of inflammation rather than just blunt it. It’s a fit if your hs-CRP (a blood marker of systemic inflammation) tends to run high-normal, if your Omega-3 Index is low, or if you’re easing back after injury or hard blocks of training. For triglyceride reduction, this 500 mg omega-3 is a maintenance dose, not a treatment dose.

EPA and DHA (the primary omega-3 fats in fish oil) are converted into 18-HEPE and 17-/14-HDHA, the “pro-resolving mediators” your immune system uses to switch from alarm to cleanup. These signals nudge neutrophils and macrophages (front-line immune cells) to clear debris and then stand down, which is why some patients see modest drops in hs-CRP and improved joint comfort. Think resolution, not suppression; the goal is a timely off‑ramp after a flare.

Take one gelcap daily with a meal that contains fat; absorption of omega-3 is better with food. Give it 4 to 8 weeks to judge recovery or comfort changes, and recheck hs-CRP or your Omega-3 Index if you track labs. If your triglycerides are elevated, pair this with a higher-dose fish oil or prescription EPA under clinician guidance, since 500 mg total omega-3 isn’t a triglyceride‑lowering dose.

Avoid if you have a fish allergy. Use caution if you have a bleeding disorder, are within two weeks of surgery, or take anticoagulants like warfarin or apixaban; omega-3s have mild anti-platelet effects at higher intakes. Data in pregnancy and breastfeeding are limited for SPM concentrates, so stick with standard prenatal DHA or discuss with your obstetric clinician before using a pro-resolving mediators supplement.